Radioionidation Reactions for Pharmaceuticals: Compendium for Effective Synthesis Strategies

by H.H. Coenen, John Mertens, Bernard Mazière

Overview

Molecules of biological interest for in-vivo and in-vitro research or diagnostics of metabolic functions and of neuro-transmission are very often labeled with iodine. Based on state-of-the-art research, this compendium describes the major production routes of the six most relevant iodine radio isotopes and the various methods of labeling molecules of biological, diagnostic or pharmaceutical interest with them.

The chapters describe the basic reaction mechanisms, and the influence of iodine introduction on physical/chemical and pharmacological properties. They also include examples of important reaction pathways for the preparation of radio-iodine compounds. The volume is completed by an expert system providing guidelines to obtain the most suitable method of synthesis regarding also cost and time aspects. Worked examples support the novices confronted with radio-iodination reactions.

Product Details

ISBN-13:	9789048171491
Publisher:	Springer Netherlands
Publication date:	11/18/2010
Edition description:	Softcover reprint of hardcover 1st ed. 2006
Pages:	101
Product dimensions:	6.30(w) x 9.45(h) x 0.01(d)

Table of Contents

Iodine Radionuclides.- Iodinated Radiopharmaceuticals.- Methods of Radioiodination.- Iodinated Radiopharmaceuticals.- Expert System.- Guidelines for Radioiodination.

Editorial Reviews

From the reviews:

"This short book is a compendium of information on the preparation of radioiodine pharmaceuticals. It is … a collection of mature, well-tested ideas about the preparation of radioiodine pharmaceuticals. … this succinct volume may be of interest to the specialist in radiopharmaceutical preparation." (Walter Loveland, JACS, Vol. 128 (48), 2006)

From the Publisher