ISBN-10:
9812835865
ISBN-13:
9789812835864
Pub. Date:
01/28/2009
Publisher:
World Scientific Publishing Company, Incorporated
Recent Advances in Iga Nephropathy

Recent Advances in Iga Nephropathy

by Kar Neng Lai

Hardcover

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Overview

Recent Advances in Iga Nephropathy

IgA nephropathy is the most common primary glomerulonephritis in developed countries. The primary defect lies in the abnormalities of the IgA molecule. The disease affects all ages, mainly in the young adults, and may recur in a transplanted kidney.This outstanding volume provides a comprehensive overview of the advances in this disease over the last ten years. It covers the genetics, epidemiology, clinicopathological features, pathogenesis, prognostic mechanisms, and treatment of this unique disease. Twenty-seven chapters are written by 43 experts from 13 countries; these experts have been providing forefront scientific findings to the scientific community for the last 20 years. The book covers all clinical, pathological and molecular aspects of IgA nephropathy.This is an essential source of reference for nephrologists, internists, pathologists, and molecular biologists. It is also suitable reading for graduate students or research scientists in the field of kidney diseases.

Product Details

ISBN-13: 9789812835864
Publisher: World Scientific Publishing Company, Incorporated
Publication date: 01/28/2009
Pages: 440
Product dimensions: 5.90(w) x 9.10(h) x 1.00(d)

Table of Contents

Contributors xi

Preface xix

1 IgA Nephropathy: Discovery of a Distinct Glomerular Disorder Keng Thye Woo Richard J. Glassock Kar Neng Lai 1

2 Epidemiology and Ancestral Difference Francesco P. Schena Francesco Pesce 9

3 Genetic Contribution to IgA Nephropathy Patrick H. Maxwell Yiming Wang 21

4 Histopathology, Immunofluorescence and Ultrastructural Examination Fernand M. Lai 37

5 Tubulointerstitial Injury in IgA Nephropathy Joris J. Roelofs Sandrine Florquin 55

6 Podocyte Pathology Kar Neng Lai Joseph C. K. Leung 69

7 Clinicopathologic Findings Bruce A. Julian Robert J. Wyatt 83

8 Clinical Course of Primary IgA Nephropathy Francois C. Berthoux Hesham Mohey 107

9 Special Clinical Syndromes Judit Nagy Tibor Kovacs 121

10 IgA Nephropathy in Children Ronald J. Hogg 139

11 Recurrent IgA Nephropathy in Transplant Bo Ying Choy Kar Neng Lai 149

12 IgA Molecule Jan-Willem Eijgenraam Mahamed R. Daha Cees van Kooten 161

13 IgA Immune-Complex Jan Novak Jiri Mestecky 177

14 B and T Lymphocytes Abdalla Rifai Ann Chen 193

15 IgA Receptors and Mesangial IgA Deposition Ivan C. Moura Renato C. Monteiro 211

16 Antigen-Dependent Mechanism of IgA Nephropathy Yasuhiko Tomino Yoshio Shimizu 225

17 Complement Activation Sydney C. W. Tang Kar Neng Lai 237

18 Cytokines and Growth Factors Jurgen Floege Tammo Ostendorf 243

19 Monocytes and Macrophages Yohei Ikezumi David J. Nikolic-Paterson 267

20 Renin-Angiotensin System Kar Neng Lai Joseph C. K. Leung 289

21 Corticosteroids Claudio Pozzi Lucia Del Vecchio 309

22 Treatment for IgA Nephropathy: Renin-Angiotensin Blockade Rosanna Coppo Licia Peruzzi 321

23 Other Immunomodulatory Agents Sydney C. W. Tang Kar NengLai 339

24 Other Non-Immunomodulatory Agents Jonathan Barratt John Feehally 349

25 Treatment of IgA Nephropathy: Tonsillectomy Osamu Hotta 369

26 Experimental Model of IgA Nephropathy Yusuke Suzuki Yasuhiko Tomino 387

27 Future Prospects for IgA Nephropathy Richard J. Glassock 403

Index 413

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