Receptor-Mediated Targeting of Drugs

Receptor-Mediated Targeting of Drugs

by G. Gregoriadis (Editor)

Paperback(Softcover reprint of the original 1st ed. 1984)

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Product Details

ISBN-13: 9781468448641
Publisher: Springer US
Publication date: 05/28/2013
Series: Nato Science Series A: (closed) , #82
Edition description: Softcover reprint of the original 1st ed. 1984
Pages: 491
Product dimensions: 7.01(w) x 10.00(h) x 0.04(d)

Table of Contents

Drug Targeting in Human Cancer Chemotherapy.- Toxic Conjugates of Epidermal Growth Factor and Asialofetuin.- Saccharide Receptor-Mediated Drug Delivery.- Study of the Transferrin Receptor Using a Cytotoxic Human Transferrin-Ricin a Chain Conjugate.- How do Protein Toxins Kill Cells?.- Role of the B-Chain in the Cytotoxic Action of Antibody-Ricin and Antibody Abrin Conjugates.- Monoclonal Antibodies as Cell Targeted Carriers of Covalently and Non-Covalently Attached Toxins.- Long-Term Kinetics of Antibody-Toxin Conjugates Show Resistant Cells.- Significance of the Kinetics of Immunotoxin Cytotoxicity.- The Use of Ricin a Chain-Containing Immunotoxins to Kill Neoplastic B Cells.- Selective Cytotoxicity of Ricin a Chain-Anti Carcinoembryonic Antibody Conjugates to Human Adenocarcinoma Cells.- Development of Monoclonal Antibodies with Specificity for Human Epithelial Cells.- Attempted Therapy of a Human Xenograft Colonic Cancer HT29 Using 131I-Labelled Monoclonal Antibodies.- Fate of Liposomes In Vivo: Control Leading to Targeting.- Interactions of Liposomes with Lipoproteins and Liver Cells In Vivo and In Vitro Studies.- Endocytosis of Liposomes and Intracellular Fate of Encapsulated Molecules: Strategies for Enhanced Cytoplasmic Delivery.- Liposomes in Leishmaniasis: The Lysosome Connection.- Thrombogenic Potential of Phosphatidylserine-Containing Liposomes.- The Use of Liposomes in Diagnostic Imaging.- Unexpected Tissue Distribution of Liposomes Coated with Amylopectin Derivatives and Successful Use in the Treatment of Experimental Legionnaires’ Diseases.- Alteration of Liposomal-Surface Properties with Synthetic Glycolipids.- Antibody-Bearing Liposomes as Probes of Receptor-Mediated Endocytosis.- Antibody-Targeted Liposomes: Development of a Cell-Specific Drug Delivery System.- Targeting and Lysosomal Handling of Polymethacrylamide-Oligopeptide Conjugates.- Drug Targeting in Cancer Therapy.- Photo.- Contributors.- Indes.

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