The following chapters comprise invited contributions from eminent scientists who are internationally recognized authorities on the subject. The chapters have been written to provide the reader with adequate background, necessary experimental details, and discussion that is easy to comprehend. The book has been organized into four different sections. The introductory chapter is meant to briefly summarize the contributions of other authors and discuss phosphorylation of receptor systems not covered in the book in detail. The chapters in the second section, on protein kinases and phosphatases, are quite fundamental to the process of phosphorylation and will aid the reader in appreciating the observations and discussions reported in other chapters. The third and fourth sections present discussions on phosphorylation of various receptor systems which are involved in mediating actions of peptide, amine, and steroid hormones. It is hoped that this book will serve as a valuable resource and will be useful to all workers and students in the area of receptor-ligand interactions.
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Table of Contents1. Introduction 2. Receptor Phosphorylation 3. Protein Kinases and Phosphatases 4. The Protein Kinase Family of Enzymes 5. Dynamic Interconversion of Receptors Involving Dephosphorylation by Protein Try (P) and SER (P)/THR (P) Phosphatases 6. Phosphorylation of Peptide Hormone Receptors 7. Function of the Insulin Receptor Kinase in the Intact Cell 8. The IGF-I Receptor Kinase 9. The Platelet-Derived Growth Factor Receptor 10. Protein Kinase C: A Mediator and Regulator of Receptor-Linked Signal 11. Phototransduction and Rhodopsin Phosphorylation 12. Phototransduction and Rhodopsin Phosphorylation 13. Phosphorylation of the b-Advantage Receptor: Mechanism of Desensitization 14. Mechanism of Transmembrane Signaling by the Epidermal Growth factor Receptor/Kinase 15. Phosphorylation of Steroid Hormone Receptors 16. Phosphorylation of the Avian Progesterone Receptor 17. Basal and Hormone-Dependent Phosphorylation of the Progesterone Receptor 18. Steroid Receptor Phosphorylation: A Regulatory Role 19. Phosphorylation and Reduction of Glucocorticoid Receptor Components 20. Association of Phosphorylation Reactions with the Glucocorticoid Receptor 21. Phosphorylation of the Estradiol Receptor on Tyrosine 22. Association of Protein Kinase Activities with Estrogen Receptors in Breast and Uterine Cells.