Refractory Depression, Current Strategies and Future Directions

Refractory Depression, Current Strategies and Future Directions


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Refractory Depression Current Strategies and Future Directions Edited by Willem A. Nolen Psychiatric Centre Bloemendaal, The Hague, The Netherlands Joseph Zohar The Chaim Sheba Medical Center, Israel Steven P. Roose New York State Psychiatric Institute, New York, USA Jay D. Amsterdam Department of Psychiatry, University of Pennsylvania, USA As many as 30% of depressed patients fail to respond to conventional antidepressant therapy, and 15% may develop a chronic unremitting depression. A variety of pharmacological, biochemical and clinical factors may contribute to this situation. However, even after making allowances for these variables, a substantial number of patients remain refractory to treatment. This text offers the clinician a broad insight into the problem of refractory depression, providing new information on the adequacy of standard treatments and the major alternatives as well as reviews of a number of other possible alternatives for those patients remaining depressed. Finally, some future directions and developments are presented which may soon lead to a better understanding of the problem of refractory depression. Written by an international field of authors, the book will be of value to all researchers and clinicians in the field of psychiatry.

Product Details

ISBN-13: 9780471943150
Publisher: Wiley
Publication date: 01/28/1994
Pages: 252
Product dimensions: 6.16(w) x 9.29(h) x 0.82(d)

Table of Contents

Partial table of contents:

Epidemiology of Refractory Depression (E. Paykel).


Selective Serotonin Reuptake Inhibitors in Refractory Depression (S. Roose).

Lithium Addition in Refractory Depression (C. de Montigny).

Refractory Depression and Electroconvulsive Therapy (M. Nobler & H. Sackeim).


The Role of Cognitive Therapy in Refractory Depression (A. Cole, et al.).

The Role of Psychostimulants in the Treatment of Depression (S. Kindler, et al.).

Alternative Approaches in Refractory Bipolar Depression (A. Nierenberg, et al.).


Assessment of Adrenocortical Activity in Refractory Depression: Steroid Suppression with Ketoconazole (J. Amsterdam, et al.).


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