Role of the Choroid Plexus in Health and Disease

by Jeppe Praetorius (Editor), Bonnie Blazer-Yost (Editor), Helle Damkier (Editor)

Overview

This book highlights the importance of the choroid plexus, which forms the blood-cerebrospinal fluid barrier and is the site of the major production of the cerebrospinal fluid (CSF). The authors show that this barrier is crucial for maintaining important compositional differences between the blood plasma and the CSF. The choroid plexus epithelial cells also prevent the spread of infectious agents and other blood-borne entities to the brain tissue.

Chapter topics range from the production of CSF by electrolyte regulation in the choroid plexus, to details on the selectively transporting nature of this barrier. Further, the authors elaborate on the important roles of CSF in sustaining brain health by providing hydration, solutes, and nutrients to the brain tissue. Readers will also learn how CSF circulates signaling molecules within the compartments of the brain and removes waste products from the brain tissue. Elucidating the regulation of these processes in thechoroid plexus is not only important for the readers’ understanding of normal brain development and function, but is also crucial for resolving a variety of cerebral challenges that lead to brain edema, as well as developing treatments for diseases. The book discusses disease models like hydrocephalus, sleep disorders, and age-related dementia.

Its comprehensive coverage makes this volume a valuable resource for researchers in cell and neurophysiology, as well as graduate students of the neurosciences.

Product Details

ISBN-13:	9781071605356
Publisher:	Springer US
Publication date:	04/18/2020
Series:	Physiology in Health and Disease
Edition description:	1st ed. 2020
Pages:	287
Product dimensions:	6.10(w) x 9.25(h) x (d)

About the Author

Jeppe Praetorius

Department of Biomedicine

Aarhus University

Aarhus

Denmark

Bonnie Blazer-Yost

Department of Biology

Indiana University – Purdue University Indianapolis

Indianapolis

Indiana

USA

Helle Damkier

Department of Biomedicine

Aarhus University

Aarhus

Denmark

Table of Contents

Structure of the Mammalian Choroid Plexus.- Blending Established and New Perspectives on Choroid Plexus-CSF Dynamics.- A Frog Model for CSF Secretion.- Cotransport of Water in the Choroid Plexus Epithelium: From Amphibians to Mammals.- The Significance of the Choroid Plexus for Cerebral Iron Homeostasis.- Acid/Base Transporters in CSF Secretion and pH Regulation.- TRPV4, a Regulatory Channel in the Production of Cerebrospinal Fluid by the Choroid Plexus.- Neuroprotective Mechanisms at the Blood-CSF Barrier of the Developing and Adult Brain.- Roles of the Choroid Plexus in Aging.- Choroid Plexus Tumors.- Roles of the Choroid Plexus in CNS Infections.- Hydrocephalus.