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Safety of Nanoparticles: From Manufacturing to Medical Applications / Edition 1
     

Safety of Nanoparticles: From Manufacturing to Medical Applications / Edition 1

by Thomas J. Webster
 

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ISBN-10: 1441926925

ISBN-13: 9781441926920

Pub. Date: 11/23/2010

Publisher: Springer New York

In spite of the potential use of nanomaterials as tissue engineering devices, implants, biosensors, drug delivery devices, etc., there has yet to be a compilation of the risks associated with the in vivo use of nanomaterials. There are numerous and well-known risks because of the size of nanoparticles. For example, nanoparticles can cross cell membranes and enter the

Overview

In spite of the potential use of nanomaterials as tissue engineering devices, implants, biosensors, drug delivery devices, etc., there has yet to be a compilation of the risks associated with the in vivo use of nanomaterials. There are numerous and well-known risks because of the size of nanoparticles. For example, nanoparticles can cross cell membranes and enter the cytoplasm undetected. The aim of this book is to provide one of the first detailed overviews of how cells and tissues in the body deal with nanoparticles. This is important not only for implantable devices, but also for the manufacturing of nanophase materials when particles can be inhaled or enter the body through the skin. Only by compiling research at the intersection of nanoparticles and biological processes can we determine if nanophase materials are safe to be manufactured, handled, and/or implanted for various medical applications.

Product Details

ISBN-13:
9781441926920
Publisher:
Springer New York
Publication date:
11/23/2010
Series:
Nanostructure Science and Technology Series
Edition description:
Softcover reprint of hardcover 1st ed. 2009
Pages:
239
Product dimensions:
6.10(w) x 9.25(h) x 0.02(d)

Table of Contents

1 Developing Practices for Safe Handling of Nanoparticles and Nanomaterials in a Development-Stage Enterprise: A Practical Guide for Research and Development Organizations Robert A. Hoerr Anand Gupta Michael J. Matuszewski 1

2 Cytotoxicity of Photoactive Naoparticles Yuhui Jin Xiaojun Zhao 19

3 Breeching Epithelial Barriers-Physiochemical Factors Impacting Nanomaterial Translocation and Toxicity Lisa DeLouise Luke Mortensen Alison Elder 33

4 Safety and Efficacy of Nano/Micro Materials Xiaohong Wei Yong-kyu Lee Kang Moo Huh Sungwon Kim Kinam Park 63

5 Biomedical Applications of Nanoparticles G.L. Prasad 89

6 Unexpected Reactions by In Vivo Applications of PEGylated Liposomes Tatsuhiro Ishida Hiroshi Kiwada 111

7 Hydrogel Nanocomposites: Biomedical Applications, Biocompatibility, and Toxicity Analysis Samantha A. Meenach Kimberly W. Anderson J. Zach Hilt 131

8 Cytotoxicity and Genotoxicity of Carbon Nanomaterials Amanda M. Schrand Jay Johnson Liming Dai Saber M. Hussain John J. Schlager Lin Zhu Yiling Hong Eiji Osawa 159

9 Calcium Phosphate Nanoparticles: Toxicology and Lymph Node Targeting for Cancer Metastasis Prevention Rajesh A. Pareta 189

10 Nanoparticles for Cancer Diagnosis and Therapy Andrew Z. Wang Frank X. Gu Omid C. Farokhzad 209

Index 237

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