Pub. Date:
Cambridge University Press
Secondary Schizophrenia

Secondary Schizophrenia

by Perminder S. Sachdev, Matcheri S. Keshavan
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Schizophrenia may not be a single disease, but the result of a diverse set of related conditions. Modern neuroscience is beginning to reveal some of the genetic and environmental underpinnings of schizophrenia; however, an approach less well travelled is to examine the medical disorders that produce symptoms resembling schizophrenia. This book is the first major attempt to bring together the diseases that produce what has been termed 'secondary schizophrenia'. International experts from diverse backgrounds ask the questions: does this medical disorder, or drug, or condition cause psychosis? If yes, does it resemble schizophrenia? What mechanisms form the basis of this relationship? What implications does this understanding have for aetiology and treatment? The answers are a feast for clinicians and researchers of psychosis and schizophrenia. They mark the next step in trying to meet the most important challenge to modern neuroscience - understanding and conquering this most mysterious of human diseases.

Product Details

ISBN-13: 9780521856973
Publisher: Cambridge University Press
Publication date: 03/31/2010
Pages: 450
Product dimensions: 7.50(w) x 9.70(h) x 1.00(d)

About the Author

Perminder S. Sachdev is Scientia Professor of Neuropsychiatry at the School of Psychiatry, University of New South Wales, and Clinical Director of the Neuropsychiatric Institute (NPI), the Prince of Wales Hospital, Sydney, Australia.

Matcheri S. Keshavan is Vice Chair of Psychiatry, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massaachusetts, USA.

Table of Contents

List of contributors vii

Preface xiii

Section 1 Introduction

1 Neurobiology and etiology of primary schizophrenia: current status Matcheri S. Keshavan Ripu D. Jindal 3

2 The concept of organicity and its application to schizophrenia Perminder S. Sachdev 16

3 Secondary hallucinations Mark Walterfang Ramon Mocellin David L. Copolov Dennis Velakoulis 21

Section 2 The neurology of schizophrenia

4 The neurologic examination in schizophrenia Richard D. Sanders Matcheri S. Keshavan 47

5 Functional neuroimaging in schizophrenia Serge A. Mitelman Jane Zhang Monte S. Buchsbaum 60

Section 3 Organic syndromes of schizophrenia

Epilepsy and schizophrenia

6 Schizophrenia-like psychosis and epilepsy Perminder S. Sachdev 79

7 Understanding the pathophysiology of schizophrenia through the looking glass of forced normalization Ennapadam S. Krishnamoorthy Seethalakshmi Ramanathan 103

Drugs and schizophrenia-like psychosis

8 Substance-induced psychosis: an overview Jagadisha Thirthalli Vivek Benegal Bangalore N. Gangadhar 112

9 Stimulants and psychosis Nash N. Boutros Matt P. Galloway Eric M. Pihlgren 127

10 Psychotomimetic effects of PCP, LSD, and Ecstasy: pharmacological models of schizophrenia? Vibeke S. Catts Stanley V Catts 141

11 Schizophrenia secondary to cannabis use Wayne Hall Louisa Degenhardt 169

12 Toxic psychosis Rajeev Kumar Jeffrey C. L. Looi 179

Other neurological disorders

13 Schizophrenia-like psychosis and traumatic brain injury Perminder S. Sachdev 186

14 Cerebrovascular disease and psychosis Osvaldo P. Almeida Sergio E. Starkstein 197

15 Neurodegenerative disorders (Alzheimer's Disease, fronto-temporal dementia) and schizophrenia-like psychosis Nicola T. Lautenschlager Alexander R Kurz 204

16 Storage disorders and psychosis Mark Walterfang Dennis Velakoulis 214

17 Mitochondrial disorders and psychosis Dennis Velakoulis and Mark Walterfang 229

18 Psychosis associated with leukodystrophies Patricia I. Rosebush Rebecca Anglin Michael Mazurek 241

19 Normal pressure hydrocephalus Julian Trollor 257

20 Brain tumors Malcolm Hopwood Lyn-May Lim 263

21 Demyelinating disease and psychosis Anthony Feinstein 273

Systemic disorders

22 Infection and schizophrenia Alan S. Brown Ezra S. Susser 279

Genetic disorders related to SLP

23 The status of genetic investigations of schizophrenia Bryan Mowry 288

24 Velocardiofacial syndrome (chromosome 22q11.2 deletion syndrome) as a model of schizophrenia Vandana Shashi Margaret N. Berry 309

25 Psychosis in Prader-Willi Syndrome Stewart L. Einfeld Sophie Kavanagh Arabella Smith Bruce J. Tonge 328

26 Friedreich's Ataxia and schizophrenia-like psychosis Perminder S. Sachdev 332

27 Wilson's Disease Edward C. Lauterbach Leslie Lester-Burns 337

28 Huntington's Disease and related disorders and their association with schizophrenia-like psychosis Perminder S. Sachdev 348

29 Fahr's Disease and psychosis Kim Burns Henry Brodaty 358

Section 4 Related concepts

30 The Charles Bonne tSyndrome William Burke 369

31 Acute brief psychosis-an organic syndrome? Anand K. Pandurangi 380

Section 5 Treatment

32 Drug treatment of secondary schizophrenia Michael D. Jibson Rajiv Tandon 393

33 Nonpharmacological interventions in secondary schizophrenia David J. Kavanagh Jennifer M. Connolly Kim T. Mueser 406

Index 419

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