Side Reactions in Peptide Synthesis

Side Reactions in Peptide Synthesis

by Yi Yang

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Product Details

ISBN-13: 9780128010099
Publisher: Elsevier Science
Publication date: 09/22/2015
Pages: 376
Product dimensions: 6.00(w) x 9.00(h) x 0.88(d)

About the Author

Yi Yang began researching peptide synthesis in 2003, and obtained his doctoral degree at Bielefeld University, Germany in 2008. Dr. Yang worked for three years at Lonza AG, Visp, Switzerland as R&D and Process Peptide Chemist, participated in multi cGMP peptidyl API production at Lonza, which is regarded as one of the largest peptide contract manufacturing organization (CMO) in the world, serving pharmaceutical companies. He is currently the Senior Research Scientist of Chemical Development, Global Pharmaceutical R&D, Ferring Pharmaceuticals A/S, Copenhagen, Denmark. Dr. Yang’s experience with a wide variety of peptide side reactions, from both practical and theoretical aspects, is ideal for this publication.

Table of Contents

  1. Peptide Fragmentation/Deletion
  2. Premature FMOC Deprotection
  3. Elimination Side Reactions
  4. Peptide Global Deprotection/Scavenger-Induced Side Reactions
  5. Peptide Rearrangement Side Reactions
  6. Side Reactions Occurring at Amino Acid/Peptide Activation Step
  7. Intramolecular Cyclization Side Reactions
  8. Side Reactions in Amino Groups in Peptide Synthesis
  9. Side Reactions in Hydroxyl, Carboxyl, Ester Groups in Peptide Synthesis
  10. Oxidation and Reduction Side Reactions in Peptide Synthesis
  11. Racemization in Peptide Synthesis
  12. Solvent and Residual Impurities in the Reagents Induced Side Reactions
  13. Dipeptide Formation Side Reactions (Redundant Amino Acid Incorporation)
  14. Reattachment of Peptides to the Solid Supports
  15. Addition Side Reactions in Peptide Synthesis
  16. Side Reactions in Phosphor Peptides
  17. Side Reactions in CYS
  18. Protein Fragmentations

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