This book deals with anabolic mechanisms which regulate eukaryotic protein synthesis, with particular emphasis on insulin and amino acids. Six chapters written by leading experts in the field provide both new data and comprehensive literature reviews. The regulation of both the eIF2 and eIF4 groups of initiation factors by signal transduction mechanisms is presented, and translation is related to cellular growth in response to nutrient and hormonal signals.
Table of Contents
Insulin Signaling and the Control of PHAS-I Phosphorylation.- Insulin, Phorbol Ester and Serum Regulate the Elongation Phase of Protein Synthesis.- Regulation of Protein Synthesis by Insulin Through IRS-1.- Regulation of Eukaryotic Initiation Factor eIF2B.- The p70 S6 Kinase Integrates Nutrient and Growth Signals to Control Translational Capacity.- Regulation of Translation Initiation by Amino Acids in Eukaryotic Cells.