Pub. Date:
Springer Berlin Heidelberg
Signaling Pathways in Liver Diseases / Edition 2

Signaling Pathways in Liver Diseases / Edition 2

by Jean-Francois Dufour, Pierre-Alain Clavien


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Product Details

ISBN-13: 9783642001499
Publisher: Springer Berlin Heidelberg
Publication date: 02/18/2010
Edition description: 2nd ed. 2010
Pages: 526
Product dimensions: 7.60(w) x 10.24(h) x 0.04(d)

About the Author

Professor Jean-François Dufour, MD, PhD, Chief, Department of Clinical Pharmacology, University Clinic Visceral Surgery and Medicine, Bern, Switzerland.
Professor Dufour is on the governing board of the European Association for the Study of the Liver (EASL). He also serves as Associate Editor for the Wiley journal Liver International and is on the editorial board for the following journals: Journal of Hepatology; Clinical Science; World Journal of Gastroenterology

Professor Pierre-Alain Clavien, MD, PhD, FACS, FRCS (Eng), FRCS (Ed), Professor and Chairman, Department of Surgery. Head, Division of Visceral & Transplantation Surgery, University Hospital Zurich, Switzerland.
Professor Clavien is a world-wide renowned surgeon-scientist, currently professor and chairman of the Department of Surgery in Zurich, Switzerland. His areas of research include organ preservation, liver ischemia-reperfusion injury and regeneration, and pathogenesis of cancer, as well as outcome research. He received many competitive grants and awards, including one of the most prestigious prices for scientific research, the Otto Naegeli Award.

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Table of Contents

Part I The Cell Types and the Matrix 1

1 Hepatocytes Giuliano Ramadori Pierluigi Ramadori 3

2 Signaling Pathways in Biliary Epithelial Cells M. Fatima Leite Viviane A. Andrade Michael H. Nathanson 25

3 Stellate Cells Fabio Marra Sara Galastri Sara Aleffi Massimo Pinzani 41

4 Signaling Pathways in Liver Diseases Kupffer Cells Christian J. Steib Alexander L. Gerbes 69

5 Hepatic Sinusoidal Endothelial Cells Robert C. Huebert Vijay H. Shah 79

6 Extracellular Matrix Scott L. Friedman 93

7 Platelets: A New Cell Type in Liver Physiology Mickael Lesurtel Pierre-Alain Clavien 105

8 Immune Cell Communication and Signaling Systems in Liver Disease Ricky H. Bhogal Simon C. Afford 117

Part II The Pathways 147

9 Toll-Like Receptors Gyongyi Szabo Pranoti Mandrekar 149

10 TNF/TNF Receptors Jörn M. Schattenberg Mark J. Czaja 161

11 Fas/FasL Maria Eugenia Guicciardi Gregory J. Gores 179

12 Interferon Signaling Markus H. Heim 189

13 NF-κB Tom Luedde Christian Trautwein 201

14 JNKs in liver diseases R. Schwabe 215

15 Insulin Pathway Miran Kim Jack R. Wands 229

16 Role of PKB/Akt in Liver Diseases Elena Zhuravleva Oliver Tschopp Brian A. Hemmings 243

17 Targeting mTOR Signaling Pathways in Liver Diseases Hala E. Thomas Sara C. Kozma 261

18 AMP-Activated Protein Kinase in Liver Louis Hue Laurent Bultot Mark H. Rider 275

19 ER Stress Signaling in Hepatic Injury Cheng Ji Neil Kaplowitz 287

20 PPARα, A Key Regulator of Hepatic Energy Homeostasis in Health and Disease Nicolas Leuenberger Walter Wahli 305

21 Bile Acids and Their Receptors Thierry Claudel Michael Trauner 317

22 Signaling Pathways in Liver Diseases: PXR and CAR Catherine A.M. Stedman Michael Downes Christopher Liddle 333

23 p53 Wen-Wei Tsai Michelle Craig Barton 345

24 The MYC Network and Cancer Snorri S. Thorgeirsson Valentina M. Factor 359

25 The WNT/β-Catenin Pathway Satdarshan P. S. Monga 367

26 Sonic Hedgehog Pathway Alessia Omenetti Anna Mae Diehl 393

27 Hypoxia-Inducible Factor-1 Signaling System Deborah Stroka Daniel Candinas 403

28 VEGF Signaling David Semela Jean-François Dufour 421

29 Apoptosis and Mitochondria Jose C. Fernández-Checa Carmen Garcia-Ruiz 439

30 Calcium Signaling Thierry Tordjmann 455

31 HBV Signaling Massimo Levrero Laura Belloni 465

32 Hepatitis C Virus and Insulin Signaling Francesco Negro Sophie Clément 483

33 MicroRNAs Onpan Cheung Arun J. Sanyal 493

34 Hepatic Clocks Ueli Schibler Gad Asher Camille Saini Jörg Morf Hans Reinke 501

Answers 513

Index 515

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