The process in which a sample of skin tissue is removed, processed, and examined with the help of a microscope is referred to as skin biopsy. This book extensively discusses various important aspects and features of skin biopsy. These include an extensive account on site selection of a skin biopsy which optimizes diagnosis of several dermatological diseases and in many cases, acts as a therapeutic intervention utilized in monitoring the response to therapy. The book also discusses role and application of skin biopsy in the complete diagnosis of specific conditions such as Langerhan cell neoplasms, pemphigus vulgaris and foliaceus, non-scarring and scarring alopecia, severe cutaneous adverse reactions and oral lichen planus. Correct diagnosis increases the scope of treatment of these complex conditions with emergence of pathogenesis and the histologic findings and constant evolution of therapeutic options.