Somatic Selection and Adaptive Evolution: On the Inheritance of Acquired Characters

Somatic Selection and Adaptive Evolution: On the Inheritance of Acquired Characters

by E.J. Steele


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Product Details

ISBN-13: 9781461597957
Publisher: Springer US
Publication date: 02/12/2012
Edition description: 1979
Pages: 92
Product dimensions: 6.10(w) x 9.25(h) x 0.01(d)

Table of Contents

1. The Problem and the Purpose.- Notes.- 2. Lamarck in Perspective.- Notes.- 3. The Central Paradox of Immunology.- The Cell Involved.- The Response to the Unexpected.- Antibody Diversity at the Molecular Level.- 1) Idiotypes.- 2) Allotypes & Isotypes.- Antibody Diversity at the Cellular Level.- Nature versus Nurture.- (a) The Myeloma Process is Non-Stochastic.- (b) Amino Acid Sequence Comparisons.- (c) RNA-DNA Hybridization.- (d) Mouse VK Germline Genes.- (e) Recapitulation.- The Problem with Rabbit Idiotypy.- Notes.- 4. The Somatic Selection Hypothesis.- The Tacit Constraints.- Somatic Ordering of Genetic Mutations.- Flow of Genetic Information in Living Systems.- Recapitulation.- Parallel Evolution 40 A Prototype Experimental Plan in the Immune System.- Rabbit Idiotypy Revisited.- Summary of the Hypothesis.- Notes.- 5. Implications and Conclusions.- Boundaries, Difficulties, Corollaries.- Implications for Immunology.- (a) Quality of Germline V Genes.- (b) Quantity of Germline V Genes.- (c) Reevaluation of the Episome Insertion Model.- High Rates of Spontaneous Mutation.- (a) The Sickle-Cell Trait and Resistance to Malaria.- (b) High Spontaneous Mutation Rates in The Mouse H-2 Complex.- (c) Male Recombination in Drosophila.- (d) Summary.- Parallel Evolution and Jerne’s Hypothesis.- The Phenomenon of Regression.- Inheritance of Acquired Autoimmune Disease?.- Experiments of Guyer and Smith.- The Endogenous Vector.- Emergence and Extinction.- Notes.- 6. Speculations on Man, Mind and Matter.- The Genetic Future of Man.- The Growth of Knowledge.- Downward Causation.- Notes.- Appendix: On the Relevance of the RNA Tumor Viruses to the Somatic Selection Hypothesis.- Exchange of Genes between Viruses and Cellular DNA.- (a) Capture of Host Cellular RNA Molecules Not Covalently Linked to Viral RNA.- (b) Covalent Capture and Transduction of Host Cellular Gene Sequences.- Speculation on Gene Selection and Integration.

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