Statistical Methods for Microarray Data Analysis: Methods and Protocols

by Andrei Y. Yakovlev (Editor), Lev Klebanov (Editor), Daniel Gaile (Editor)

Overview

Microarrays for simultaneous measurement of redundancy of RNA species are used in fundamental biology as well as in medical research. Statistically,a microarray may be considered as an observation of very high dimensionality equal to the number of expression levels measured on it. In Statistical Methods for Microarray Data Analysis: Methods and Prools, expert researchers in the field detail many methods and techniques used to study microarrays, guiding the reader from microarray technology to statistical problems of specific multivariate data analysis. Written in the highly successful Methods in Molecular Biology™ series format, the chapters include the kind of detailed description and implementation advice that is crucial for getting optimal results in the laboratory.

Thorough and intuitive, Statistical Methods for Microarray Data Analysis: Methods and Prools aids scientists in continuing to study microarrays and the most current statistical methods.

Product Details

ISBN-13:	9781603273367
Publisher:	Springer New York
Publication date:	02/06/2013
Series:	Methods in Molecular Biology , #972
Edition description:	2013
Pages:	212
Product dimensions:	6.90(w) x 10.00(h) x 0.80(d)

Table of Contents

What Statisticians Should Know About Microarray Gene Expression Technology.- Where Statistics and Molecular Microarray Experiments Biology Meet.- Multiple Hypothesis Testing: A Methodological Overview.- Gene Selection with the d-sequence Method.- Using of Normalizations for Gene Expression Analysis.-Constructing Multivariate Prognostic Gene Signatures with Censored Survival Data.- Clustering of Gene-Expression Data via Normal Mixture Models.- Network-based Analysis of Multivariate Gene Expression Data.- Genomic Outlier Detection in High-throughput Data Analysis.- Impact of Experimental Noise and Annotation Imprecision on Data Quality in Microarray Experiment.- Aggregation Effect in Microarray Data Analysis.- Test for Normality of the Gene Expression Data.

Editorial Reviews

This book covers a broad range of topics, from the normalization of expression levels to the evaluation of experimental noise or the identification of putative networks through either multivariate analysis approach or clustering. … It is therefore appropriate for research students and post-docs as well as lecturers looking for handson examples.” (Irina Ioana Mohorianu, zbMATH 1312.92006, 2015)

From the Publisher