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Statistical Monitoring of Clinical Trials: Fundamentals for Investigators / Edition 1
     

Statistical Monitoring of Clinical Trials: Fundamentals for Investigators / Edition 1

by Lemuel A. Moye, Lemuel A. Moy
 

ISBN-10: 0387277811

ISBN-13: 9780387277813

Pub. Date: 11/16/2005

Publisher: Springer New York

Statistical Monitoring of Clinical Trials: Fundamentals for Investigators introduces the investigator and statistician to monitoring procedures in clinical research. Clearly presenting the necessary background with limited use of mathematics, this book increases the knowledge, experience, and intuition of investigations in the use of these important procedures

Overview

Statistical Monitoring of Clinical Trials: Fundamentals for Investigators introduces the investigator and statistician to monitoring procedures in clinical research. Clearly presenting the necessary background with limited use of mathematics, this book increases the knowledge, experience, and intuition of investigations in the use of these important procedures now required by the many clinical research efforts. The author provides motivated clinical investigators the background, correct use, and interpretation of these monitoring procedures at an elementary statistical level. He defines terms commonly used such as group sequential procedures and stochastic curtailment in non-mathematical language and discusses the commonly used procedures of Pocock, O'Brien-Fleming, and Lan-DeMets. He discusses the notions of conditional power, monitoring for safety and futility, and monitoring multiple endpoints in the study. The use of monitoring clinical trials is introduced in the context of the evolution of clinical research and one chapter is devoted to the more recent Bayesian procedures.

Product Details

ISBN-13:
9780387277813
Publisher:
Springer New York
Publication date:
11/16/2005
Edition description:
2006
Pages:
254
Product dimensions:
6.10(w) x 9.25(h) x 0.02(d)

Related Subjects

Table of Contents

Here, There be dragons….- The Basis of Statistical Reasoning in Medicine.- Probability Tools for Monitoring Rules.- Issues and Intuition in Path Analysis.- Group Sequential Analysis Procedures.- Looking Forward: Conditional Power.- Safety and Futility.- Bayesian Statistical Monitoring.

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