Stem Cell Biology and Gene Therapy / Edition 1 available in Hardcover
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STEM CELL BIOLOGY AND GENE THERAPYEdited by Peter J. Quesenberry, Gary S. Stein, Bernard Forget, andSherman WeissmanAdvances in molecular genetics and recombinant DNA technology haveushered in a new era in medical therapeutic research. New insightsinto the molecular basis of human disease and the role played bybiological regulatory mechanisms have precipitated tremendous drugdevelopment efforts backed by intensive research into human genetherapy worldwide.Stem Cell Biology and Gene Therapy is the first book to thoroughlycover major advances in the field and their applications to novelmolecular therapies.This self-contained volume integrates biological and clinicalcomponents of stem cell biology, examines some of the mostdifficult aspects of gene therapy, and provides a systematic reviewof advanced gene modification techniques. Twenty essays by leadingresearchers address some of the most compelling topics incontemporary medical research, including:* Fundamental regulatory mechanisms that operate in stemcells* Stem cells from a therapeutic perspective, including preparationsof stem cells and their therapeutic potential as vehicles for genetherapy* Delivery systems for therapeutic genes, including an overview ofthe most promising vectors* Clinical applications for gene therapy, covering a broad range ofdiseases such as hemophilia, cancers, neurological disease, andmoreComplete with illustrations and real-world examples of a variety ofdisorders, Stem Cell Biology and Gene Therapy is essential forresearchers in gene therapy and members of the biotechnologyindustry who are developing human molecular therapies forcommercial use. It is also an important reference for molecularbiologists, cell biologists, immunologists, molecular geneticists,hematologists, cancer researchers, biochemists, and anyone workingin internal medicine.
|Product dimensions:||6.42(w) x 9.53(h) x 1.30(d)|
Table of Contents
Stem Cell Systems: Basic Principles and Methodologies (S. Nilsson& P. Quesenberry).Cytokine/Growth Factor Responsiveness of Early HemopoieticProgenitor Cells (A. Burgess).Molecular Mechanisms Controlling the Cell Cycle andProliferation-Differentiation Interrelationships (G. Stein, etal.).Stem Cell Transcription (S. Weissman & A. Perkins).Hematopoietic Stem Cells: Proliferation, Purification and ClinicalApplications (R. Pettengell & M. Moore).Delivery Systems for Gene Therapy: The Adenovirus (T. Shenk).Gene Transfer to Muscle and Spinal Cord Using Herpes SimplexVirus-Based Vectors (J. Huard, et al.).Herpes Virus Vectors (X. Breakefield, et al.).Delivery Systems for Gene Therapy: Adeno-Associated Virus (G.Kroner-Lux, et al.).Delivery Systems for Gene Therapy: Adeno-Associated Virus 2 (A.Srivastava).Ribozyme Gene Therapy Targeting Stem Cells for HumanImmunodeficiency Virus Infection (A. Ho, et al.).Elements of DNA Vaccine Design (M. Caufield & M. Liu).Development of Gene Therapy for Gaucher Disease (J. Barranger, etal.).Clinical Applications of Gene Therapy: Correction of GeneticDisease Affecting Hematopoietic Cells (J. Medin, et al.).Gene Therapy for Hemophilia (K. High).Clinical Applications of Gene Therapy: Anemias (G. Atweh & B.Forget).Clinical Applications of Gene Therapy in Cancer: Modification ofSensitivity to Therapeutic Agents (T. Licht, et al.).Clinical Applications of Gene Therapy: Brian Tumors (K. Culver& J. Van Gilder).Clinical Applications of Gene Therapy: Cardiovascular Disease (J.Fox).Applications of Gene Therapy to Neurological Diseases and Injuries(D. Choi-Lundberg & M. Bohn).Index.