This book discusses the main stem cell niches under distinct pathophysiological conditions. The role of tissue microenvironments in stem cell regulation, as well as modern methodologies and new techniques for the identification and characterization of stem cell niches, are discussed by leading experts in the field. Chapters describe the major components of various stem cell microenvironments, such as cellular components, soluble factors, cell-cell interactions, extra-cellular matrix proteins, and physical forces.Stem Cell Microenvironments and Beyondis part of the highly successfulAdvances in Experimental Medicine and Biologyseries. It is essential reading for graduate students and researchers in the field of stem cells or cell biology as well as clinicians.
About the Author
Alexander Birbrair received his Bachelor’s Biomedical degree from Santa Cruz State University in Brazil. He moved to North Carolina, where he finished his PhD in Neuroscience under the mentorship of Osvaldo Delbono. Then, he joined as a posdoc in Stem Cell Biology at Paul Frenette’s laboratory at Albert Einstein School of Medicine. In 2016, he was appointed faculty at Federal University of Minas Gerais in Brazil, where he started his own lab. His laboratory is interested in understanding how the cellular components of different tissues function and control disease progression. His group explores the roles of specific cell populations in the tissue microenvironment by using state-of-the-art techniques.
Table of Contents1. Stem Cell Microenvironments and Beyond.- 2. The bone marrow microenvironment for hematopoietic stem cells.- 3. Leukemia stem cells microenvironment.- 4. Developmental HSC Microenvironments: Lessons from Zebrafish.- 5. Spinal cord stem cells microenvironment: the ependyme as a stem cell niche.- 6. Being a Neural Stem Cell: a matter of character but defined by the microenvironment.- 7. Glioblastoma Stem Cells and their Microenvironment.- 8. Plasticity of the Muscle Stem Cell Microenvironment.- 9. The Macula Flava of the Human Vocal Fold as a Stem Cell Microenvironment.- 10. Oesophageal stem cells microenvironment.- 11. Oral cancer stem cells microenvironment.- 12 Fetal membranes-derived stem cells microenvironment.- 13. Current technologies based on the knowledge of the stem cells microenvironments.