Stem cell research can not only develop potential sources of cells for endocrine therapy, but can also allow the study of organ development ex vivo using isolated and defined stem cell precursors. In Stem Cells in Endocrinology, leading stem cell biologists and developmental endocrinologists critically review both cutting-edge approaches to stem cell biology and the application of stem cells to endocrine diseases, including diabetes, infertility, and liver-associated metabolic disorders. The authors discuss current research to modify stem cells, develop an endocrine-like cell, and use adult bone marrow stem cells to treat autoimmune diseases, including endocrine-based autoimmune diseases. Topics of interest include a review of all stem cell subtypes and their characteristics, approaches to promoting endocrine development from stem cells, and evidence for endocrine cell function from stem cells. The authors also outline how best to develop preclinical studies that will determine the safety and efficacy of stem cell therapies for endocrine disorders. Background chapters provide a basic understanding of stem cell biology and introduce all major types of stem cells, including embryonic, adult, cord blood, and germ line.
State of the art and forward looking, Stem Cells in Endocrinology offers the basic and clinician scientist an authoritative evaluation of all aspects of how stem cells might be used to create endocrine cells and to treat such diseases as type 1 diabetes.
Table of Contents
Part I: Basic Stem Cell Biology
Embryonic Stem Cells: Derivation, Properties, and Therapeutic Implications
Victoria L. Browning and Jon S. Odorico
Germ Line Stem Cells
Makoto C. Nagano
Umbilical Cord Stem Cells
Kathy E. Mitchell
Differentiation Potential of Adult Stem Cells
Henry E. Young and Asa C. Black, Jr.
Growth Conditions for Primate vs Murine Embryonic Stem Cells
Gillian M. Beattie, Nathan Bucay, Rohan Humphrey, Ana D. Lopez, and Alberto Hayek
Part II: Translational Research
Islet Precursor Cells in Adult Pancreatic Islets
Gladys Teitelman and Irem Nasir
Transcription Factor-Directed Differentiation of Stem Cells Along an Endocrine Lineage
William L. Lowe, Jr.
Generation of Islet-Like Structures From ES Cells
The Therapeutic Potential of Liver Repopulation for Metabolic or Endocrine Disorders
The Manipulation of Mesenchymal Stem Cells for Bone Repair
Shelley R. Winn
Spermatogenesis From Transplanted Spermatogenic Stem Cells
Michael D. Griswold and Derek McLean
Hematopoietic Stem Cell Transplant in the Treatment of Autoimmune Endocrine Disease
Jody Schumacher and Ewa Carrier
Preclinical Trials for Stem Cell Therapy
Linda B. Lester, K. Y. Francis Pau, and Don P. Wolf