ISBN-10:
0323295444
ISBN-13:
9780323295444
Pub. Date:
09/07/2015
Publisher:
Elsevier Health Sciences
Stroke: Pathophysiology, Diagnosis, and Management / Edition 6

Stroke: Pathophysiology, Diagnosis, and Management / Edition 6

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Overview

Offered in print, online, and downloadable formats, this updated edition of Stroke: Pathophysiology, Diagnosis, and Management delivers convenient access to the latest research findings and management approaches for cerebrovascular disease. Picking up from where J. P. Mohr and colleagues left off, a new team of editors — Drs. Grotta, Albers, Broderick, Kasner, Lo, Mendelow, Sacco, and Wong — head the sixth edition of this classic text, which is authored by the world’s foremost stroke experts.

  • Comprehensive, expert clinical guidance enables you to recognize the clinical manifestations of stroke, use the latest laboratory and imaging studies to arrive at a diagnosis, and generate an effective medical and surgical treatment plan.
  • Abundant full-color CT images and pathology slides help you make efficient and accurate diagnoses.
      • Data from late-breaking endovascular trials equips you with recent findings.
      • Includes comprehensive coverage of advances in molecular biology of cell death; risk factors and prevention; advances in diagnostics and stroke imaging; and therapeutic options, including a thorough review of thrombolytic agents and emerging data for endovascular therapy.
      • Features brand-new chapters on Intracellular Signaling: Mediators and Protective Responses; The Neurovascular Unit and Responses to Ischemia; Mechanisms of Cerebral Hemorrhage; Stroke Related to Surgery and Other Procedures; Cryptogenic Stroke; and Interventions to Improve Recovery after Stroke.
      • Highlights new information on genetic risk factors; primary prevention of stroke; infectious diseases and stroke; recovery interventions such as robotics, brain stimulation, and telerehabilitation; and trial design.
      • Details advances in diagnostic tests, such as ultrasound, computed tomography (including CT angiography and CT perfusion), MRI (including MR perfusion techniques), and angiography.
      • Includes extracted and highlighted evidence levels.
      • Expert Consult eBook version included with print purchase. This enhanced eBook experience allows you to search all of the text, figures, and references on a variety of devices. The content can also be downloaded to tablets and smart phones for offline use.

      Combatstroke with the most comprehensive and updated multimedia resource on the pathophysiology, diagnosis, and management of stroke from leaders in the field

      Product Details

      ISBN-13: 9780323295444
      Publisher: Elsevier Health Sciences
      Publication date: 09/07/2015
      Edition description: New Edition
      Pages: 1504
      Sales rank: 705,292
      Product dimensions: 8.80(w) x 11.10(h) x 2.10(d)

      About the Author

      Eng H. Lo. Ph.D. (Editor)

      Massachusetts General Hospital, Harvard Medical School, Boston, MA Dr. Lo is currently Head of the Neuroprotection Research Laboratories at Massachusetts General Hospital and Professor of Neuroscience in Harvard Medical School. For over 25 years, Dr. Lo has contributed to research delineating mechanisms of injury and repair in the central nervous system.

      Professor of Neurology, Chairman, Department of Neurology, University of Texas Medical School at Houston; Director, Stroke Program, Memorial Hermann - Texas Medical Center, Houston, TX

      Eng H. Lo. Ph.D. (Editor)

      Massachusetts General Hospital, Harvard Medical School, Boston, MA Dr. Lo is currently Head of the Neuroprotection Research Laboratories at Massachusetts General Hospital and Professor of Neuroscience in Harvard Medical School. For over 25 years, Dr. Lo has contributed to research delineating mechanisms of injury and repair in the central nervous system.

      Table of Contents

      SECTION I: Pathophysiology

      1 Vascular Biology and Atherosclerosis of Cerebral Vessels

      2 Mechanisms of Thrombosis and Thrombolysis

      3 Cerebral Blood Flow and Metabolism: Regulation and Pathophysiology in Cerebrovascular Disease

      4 Histopathology of Brain Tissue Response to Stroke and Injury

      5 Molecular and Cellular Mechanisms of Ischemia-Induced Neuronal Death

      6 Intracellular Signaling: Mediators and Protective Responses

      7 The Neurovascular Unit and Responses to Ischemia

      8 Mechanisms of Cerebral Hemorrhage

      9 White Matter Pathophysiology

      10 Inflammation and Immune Response

      11 Mechanisms of Plasticity, Remodeling and Recovery

      12 Genetics and Vascular Biology of Angiogenesis and Vascular Malformations

      SECTION II: Epidemiology and Risk Factors

      13 Global Burden of Stroke

      14 Stroke Disparities

      15 Modifiable Risk Factors and Determinants of Stroke

      16 Prognosis after Stroke

      17 Vascular Dementia and Cognitive Impairment

      18 Genetic Basis of Stroke Occurrence, Prevention and Outcome

      19 Preventing a First Stroke

      SECTION III: Clinical Manifestations 20 Classification of Ischemic Stroke

      21 Clinical Scales to Assess Patients with Stroke

      22 Carotid Artery Disease

      23 Anterior Cerebral Artery Disease

      24 Middle Cerebral Artery Disease

      25 Posterior Cerebral Artery Disease

      26 Vertebrobasilar Disease

      27 Lacunar Syndromes, Lacunar Infarcts, and Cerebral Small Vessel Disease

      28 Intracerebral Hemorrhage

      29 Aneurysmal Subarachnoid Hemorrhage

      30 Arteriovenous Malformations and Other Vascular Anomalies

      31 Stroke and Other Vascular Syndromes of the spinal Cord

      SECTION IV: Specific Conditions and Stroke

      32 Cardiac Diseases

      33 Atherosclerotic Disease of the Proximal Aorta

      34 Stroke Related to Surgery and Other Procedures

      35 Arterial Dissections and Fibromuscular Dysplasia

      36 Collagen Vascular and Infectious Diseases

      37 Reversible Cerebral Vasoconstriction Syndromes

      38 Hypertensive Encephalopathy

      39 Stroke and Substance Abuse

      40 Moyamoya Disease

      41 CADASIL: Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy

      42 Hematologic Disorders and Stroke

      43 Migraine and Stroke

      44 Cryptogenic Stroke

      45 Cerebral Venous Thrombosis

      SECTION V: Diagnostic Studies

      46 Ultrasonography

      47 Computed Tomography-based Evaluation of Cerebrovascular Disease

      48 Magnetic Resonance Imaging of Cerebrovascular Diseases

      49 Cerebral Angiography

      SECTION VI: Therapy

      Part A: Medical Therapy

      50 Prehospital and Emergency Department Care of the Patient with Acute Stroke

      51 Intravenous Thrombolysis

      52 Antithrombotic Therapy for Treatment of Acute Ischemic Stroke

      53 General Stroke Management and Stroke Units

      54 Critical Care of the Patient with Acute Stroke

      55 Pharmacologic Modification of Acute Cerebral Ischemia

      56 Treatment of "Other" Stroke Etiologies

      57 Medical Therapy of Intracerebral and Intraventricular Hemorrhage

      58 Rehabilitation and Recovery of the Patient with Stroke

      59 Interventions to Improve Recovery after Stroke

      60 Enhancing Stroke Recovery with Cellular Therapies

      61 Antiplatelet Therapy for Secondary Prevention of Stroke

      62 Secondary Prevention of Cardioembolic Stroke

      63 Conduct of Stroke-Related Clinical Trials

      Part B: Interventional Therapy

      64 Endovascular Therapy of Extracranial and Intracranial Occlusive Disease

      65 Endovascular Treatment of Acute Ischemic Stroke

      66 Endovascular Treatment of Cerebral Aneurysms

      67 Interventional Therapy of Brain and Spinal Arteriovenous Malformations

      68 Dural Arteriovenous Malformations

      Part C: Surgical Therapy

      69 Surgery of Anterior and Posterior Aneurysms

      70 Surgery for Intracerebral Hemorrhage

      71 Intraventricular Hemorrhage

      72 Surgical Management of Cranial and Spinal Arteriovenous Malformations

      73 Surgical Cavernous Malformations and Venous Anomalies

      74 Indications for Carotid Endarterectomy in Patients with Asymptomatic and Symptomatic Carotid Stenosis

      75 Extracranial to Intracranial Bypass for Cerebral Ischemia

      76 Decompressive Craniectomy for Infarction and Hemorrhage

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