Structure, Function and Regulation of TOR complexes from Yeasts to Mammals: Part B

Structure, Function and Regulation of TOR complexes from Yeasts to Mammals: Part B

by Elsevier Science

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Structure, Function and Regulation of TOR complexes from Yeasts to Mammals: Part B by Elsevier Science

This volume of The Enzymes features high-caliber thematic articles on the topic of glycosylphosphatidylinositol (GPI) anchoring of proteins.

  • Contributions from leading authorities
  • Informs and updates on all the latest developments in the field

Product Details

ISBN-13: 9780123810069
Publisher: Elsevier Science
Publication date: 11/18/2010
Series: Enzymes , #28
Sold by: Barnes & Noble
Format: NOOK Book
Pages: 400
File size: 3 MB

About the Author

Fuyu Tamanoi is a biochemist who has served on the UCLA School of Medicine and UCLA College faculty since he joined the Department of Microbiology, Immunology&Molecular Genetics in 1993. He became a full professor in 1997. Since 1996, he has been a Director of Signal Transduction Program Area at Jonsson Comprehensive Cancer Center. Dr. Tamanoi earned his B.S. and M.S. in Biochemistry at the University of Tokyo. He received PhD in Molecular Biology at Nagoya University in 1977. He was a postdoctoral fellow at Harvard Medical School, where he worked on bacteriophage DNA replication. From 1980 to 1985, he was a senior staff investigator at Cold Spring Harbor Laboratory, where he worked on adenovirus DNA replication. From 1985 to 1993, he was an Assistant Professor and then Associate Professor at the University of Chicago, where he initiated studies on lipid modification of the Ras family proteins. His laboratory research centers on signal transduction and signal transduction inhibitors. He is currently exploring ways to deliver signal transduction inhibitors using nanoparticles.

Table of Contents

Chapter 1: Overview of GPI biosynthesis, gene list
Taroh Kinoshita

Chapter 2: GlcNAc transfer reaction, GPI-GnT, Ras signaling
David E. Levin

Chapter 3: GlcNAc-PI de-N-acetylase
Michael A. J. Ferguson

Chapter 4: Inositol acylation/deacylation
Yoshifumi Jigami

Chapter 5: Mannosylation
Yusuke Maeda

Chapter 6: Phosphoethanolamine transfer
Peter Orlean

Chapter 7: Transamidase
Anant K. Menon

Chapter 8: Flipping and pathway topology
Anant Menon

Chapter 9: Evolutional conservation and Bioinformatics
John Samuelson

Chapter 10: GPI in apicomplexan and parasites
Ralph Schwarz

Chapter 11: Chemical synthesis of GPI
Ram A. Vishwakarma

Chapter 12: Use of synthetic GPIs as anti-toxic vaccine
Peter Seeberger

Chapter 13: ER export and GPI-proteins
Howard Riezman

Chapter 14: Polarized sorting of GPI proteins
Chiara Zurzolo

Chapter 15: Involvement of GPIs in yeast cell wall structure
Peter N. Lipke

Chapter 16: Paroxysmal nocturnal hemoglobinuria (PIGA mutation)
Lucio Luzzatto

Chapter 17: Inherited GPI deficiency
Anastasios Karadimitris

Chapter 18: Inhibitors of GPI biosynthesis
Terry K. Smith

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