Providing a broad overview of a recently recognized consequence of ischemic heart disease - stunned myocardium - this reference book presents the definition, characteristics, and mechanisms of the phenomenon in various experimental models of ischemia/reperfusion and describes the clinical situations in which stunned myocardium is present.;Describing the evidence that has elucidated the properties of this condition, this book delineates current theories on the mechanisms of stunned myocardium, including the role of oxygen radicals and altered calcium homeostasis. It also examines stunning in such cases as single coronary artery occlusion, repetitive coronary artery occlusion, partial coronary stenosis and global ischemia.
Table of Contents
What is stunned myocardium? - stunned myocardium - historical perspectives, Guy R. Heyndrickx and Stephen F. Vatner, first evidence - postischemic dysfunction of viable myocardium, Robert A. Kloner and Karin Przyklenk, metabolic correlates of reversibly injured myocardium - myocardial oxygen consumption and carbon substrate utilization, Stevan D. Zimmer and Robert J. Bache, stunned myocardium in models of repeated coronary occlusion, Mengjia Zhao et al, stunned myocardium following exercise-induced ischemia, David C. Homans, stunned myocardium in the isolated perfused heart preparation, Karin Przyklenk and Carl S. Apstein, is stunned myocardium a protective mechanism?, Keith A.Reimer and Robert B.Jennings; mechanisms of postischemic dysfunction - role of oxygen radicals in myocardial stunning, Roberto Bolli, role of altered calcium homeostasis in stunned myocardium, Hideo Kusuoka and Eduardo Marban, role of the cyclooxygenase pathway in stunned myocardium, Neil E. Farber and Garrett J. Gross, other theories - myths, fads, or facts?, Karin Przyklenk and Peter Whittaker, the stunned myocardium - a complex phenomenon demands an integrated explanation, Winifred G. Nayler; treatment for the stunned myocardium inotropic agents and stimulation of stunned myocardium, Lewis C. Becker, calcium antagonists as treatments for the stunned myocardium, Karin Przyklenk and Robert A. Kloner, beta blockers, Garrett J. Gross, prostacyclinmimetics and steroids, Garrett J. Gross, angiotensin converting enzyme inhibitors, Karin Przyklenk; stunned myocardium and the clinician - stunned myocardium in patients reperfused for the treatment of acute myocardial infarction, Robert A. Kloner, stunned myocardium in angioplasty, Edward S. Murphy et al, stunned myocardium postexercise, Robert A. Kloner and John W. Allen, stunned myocardium in cardiac surgery, Ian C. Wilson and Timothy J. Gardner, noninvasive identification and characterization of blood flow and metabolic alterations in myocardial stunning with positron emission tomography, Heinrich R. Schelbert and Denis Buxton, stunned myocardium is important for the cardiovascular surgeon, Gregory Louis Kay et al, is stunned myocardium important from a clinical standpoint?, Eugene Braunwald.