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Survival: A Medical Memoir: From Drug Discovery To Clinical Cancer Trials

Survival: A Medical Memoir: From Drug Discovery To Clinical Cancer Trials

Survival: A Medical Memoir: From Drug Discovery To Clinical Cancer Trials

Survival: A Medical Memoir: From Drug Discovery To Clinical Cancer Trials



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This is the amazing true story of medical research, far outside the box, that led to the discovery of a novel antihistamine (DPPE) that helped chemotherapy drugs cure laboratory mice of cancer while protecting the bone marrow. The book chronicles an inventor's passion to move DPPE from the laboratory to the clinic; the unprecedented facilitation of its development and approval for human use by university and government bureaucrats; the decision of a U.S. pharmaceutical giant that stopped DPPE in its tracks after it was declared inactive at an early time-point in a major breast cancer trial, only to show a marked survival advantage in a follow-up analysis 18 months later; and its dramatic rescue by a small Canadian biotech company that, with a combination of luck, venture capital and the FDA's blessing, took it back into a final trial needed for its approval. Intertwined with the human drama are the politics and science behind the story, including an unanticipated research finding with implications that shook the public, drug companies and regulatory agencies.

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Product Details

BN ID: 2940157834418
Publisher: FriesenPress
Publication date: 03/30/2016
Sold by: Barnes & Noble
Format: eBook
Pages: 606
File size: 9 MB

About the Author

Lorne Brandes received his MD (cum laude) from the University of Western Ontario in 1968, and his Fellowship in Internal Medicine from the Royal College of Physicians and Surgeons of Canada. Following his internship and first year of residency at Western, he was privileged to spend 1970-71 with chemotherapy pioneers, Drs. David Galton and Eve Wiltshaw, at the Royal Marsden Hospital (London). He then completed his training in hematology/oncology at the University of Manitoba under Dr. Lyonel Israels, one of Canada’s foremost hematologists and medical researchers. Dr. Brandes joined the Faculty of Medicine at U. of M. in 1975, where he rose through the ranks to become a tenured professor in the Department of Medicine and the Section of Hematology/Oncology at CancerCare Manitoba (previously known as the Manitoba Cancer Treatment and Research Foundation). In addition to his oncology practice, he conducted laboratory research that resulted in a drug discovery that he took into human clinical cancer trials.

Over the years, he treated most types of cancer, but subsequently limited his practice to breast and prostate cancer. Until his retirement in September, 2015, he greatly enjoyed teaching the art and science of oncology to the many students and post-graduate physicians who rotated through his clinics.

An avid reader and lover of the arts, he plays classical piano and keeps up to date on medical science. From 2007 to 2012, he wrote health blogs for He and his wife, Jill, have two children and four grandchildren, all in Winnipeg.

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