This ready reference not only presents the hot and emerging topic of modern flow chemistry, it is also unique in illustrating the important connection to sustainable chemistry.
Focusing on more sustainable methods and applications, the text extensively covers every important field from reaction time optimization to waste minimization, and from safety improvements to microwave applications. In addition, green metrics are presented as a key aspect of the book, helping readers to evaluate the efficiency of flow technologies and their impact on the overall efficiency of a chemical process.
An invaluable handbook for every chemist working in the laboratory, whether in academia or industry.
|Product dimensions:||6.80(w) x 9.80(h) x 0.80(d)|
About the Author
Luigi Vaccaro is a Professor of Organic Chemistry (habilitated in 2013 as full Professor) at the Università degli Studi di Perugia-Italy and is a Guest Professor (Bijzonder Gastdocent) at the University of KU Leuven-Belgium. He is also an Associate Editor of the journals RSC Advances and Beilstein Journal of Organic
Chemistry, and a member of the FWO WT&4 Chemistry expert panel and of the OECD-EPA commission on substitution of toxic substances. Prof. Vaccaro is leading the Green S.O.C. group in Perugia and is dedicating his research and teaching activity to the development of sustainable tools for minimizing waste and accessing cleaner products. He is currently focusing on the identification and use of novel biomass-derived solvents and on the design and synthesis of novel polymeric matrices for the preparation of heterogeneous catalytic systems suitable for being used in flow and green reaction media. Recent applications are directed toward the definition of sustainable protocols for cross-coupling and C-H activation processes aimed at the clean synthesis of organic semiconductors and target materials. Luigi
Vaccaro is author of ca. 130 scientific publications and received the Europa Medal from Society of Chemical Industry - London (2001), the ADP Award from Merck's Chemistry Council for "Creative work in organic chemistry" (2006 and 2007), the G. Ciamician Medal of the Società Chimica Italiana (2007) and the Vigevani Visiting Professorship (2014).
Table of Contents
ForewordFLOW PHOTOCHEMISTRY - A GREEN TECHNOLOGY WITH A BRIGHT FUTUREIntroduction to Synthetic Organic PhotochemistryConventional Batch PhotochemistryContinuous-Flow ChemistrySelected Examples of Photochemical Reactions under Flow ConditionsSummary, Conclusion, and OutlookCONTINUOUS FLOW SYNTHESIS USING RECYCLABLE REACTION MEDIAIntroductionContinuous Flow Reactions Using an Ionic LiquidContinuous Flow Reactions Using a Fluorous SolventConclusionsSYNTHESIS AND APPLICATION OF H2O2 IN FLOW REACTORSIntroductionThe Synthesis of Hydrogen Peroxide from Hydrogen and Oxygen in Flow Process with MicrotechnologyApplication of Hydrogen Peroxide in MicroreactorsConclusionsSCALE-UP OF FLOW PROCESSES IN THE PHARMACEUTICAL INDUSTRYIntroductionStages of Pharmaceutical DevelopmentSustainability of Supply - The Role of Continuous ProcessingComparison of Batch to Continuous Large-Scale ProcessingScale-Up of a Flow ProcessFlow Processes in the Manufacture of Pharmaceuticals: Examples of Scale-UpSummary and Outlook on Future Scale-UpORGANIC SYNTHESIS IN FLOW: TOWARD HIGHER LEVELS OF SUSTAINABILITYIntroductionSemi-Automated OptimizationSelf-Optimizing Microreactor SystemsSustainability in Microreactor TechnologyConclusionSUSTAINABLE FLOW CHEMISTRY IN DRUG DISCOVERYIntroductionLaboratory EquipmentAdvantages of Improved SustainabilitySustainable Drug DiscoveryConclusions and OutlookFLOW TOOLS TO DEFINE WASTE/TIME/ENERGY-MINIMIZED PROTOCOLSIntroductionMinimization of Solvents and Reuse of Catalytic SystemsTime/Cost/Energy Saving Examples Using Flow ApproachConclusionsTHE APPLICATION OF FLOW CHEMISTRY IN THE USE OF HIGHLY REACTIVE INTERMEDIATES AND REAGENTSIntroductionHydrogenation Reactions in FlowCarbonylation in FlowOrganometallic Reagents in FlowSynthesis of Azides and Diazoacetates in FlowThe Use of Flow Reactors to Prepare Unstable Intermediates Using PhotochemistryThe Use of Flow Reactors to Prepare Unstable Intermediates Using ElectrochemistryFluorination and Trifluoromethylation in FlowConclusionsNONCONVENTIONAL TECHNIQUES IN SUSTAINABLE FLOW CHEMISTRYIntroductionMicrowave-Assisted Flow ChemistryInductive Heating in Flow ChemistrySonochemistry in Flow ChemistryOrganic Electrochemistry in Flow ChemistryConclusionsLIFE CYCLE ASSESSMENT OF FLOW CHEMISTRY PROCESSESIntroductionEnvironmental Sustainability AssessmentFlow Processes LCA Case StudiesConclusionsSOLIDS IN CONTINUOUS FLOW REACTORS FOR SPECIALTY AND PHARMACEUTICAL SYNTHESESIntroductionMechanisms of Solids Formation in Flow ReactorsManufacture of Solids in Flow: Soft Particles and APIsUse of Solids Suspension Catalyst in FlowAvoiding Blockage of Flow Reactors by Insoluble By-Products: Flow FocusingGreen Engineering AspectsIndex