Sweet Sue follows the lives of five wild teenagers from the 1930's to the year 2005 as they mature, go to war, have sex, get married and die mysterious deaths. All five are players in a band and close friends at the start whose lives intertwine and diverge as they grow up. The main character, Alex Hibriten, is tomented by his affair with a sexy sultry singer and must come to grips with what appears to be a government conspiracy as well as a father who may be a spy and a mysterious woman who claims to be his mother. Throughout an otherwise successful career and marriage, he is haunted by ghostlike apparitions and mysterious deaths that occur. He fears for his life as the conspiracy tightens around him.