Systemic Lupus Erythematosus

Systemic Lupus Erythematosus

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Systemic Lupus Erythematosus by Robert G. Lahita

The immune system normally protects the body against viruses, bacteria, and other foreign materials. Systemic Lupus Erythematosus (usually called, simply, lupus) is a chronic, autoimmune disease which causes inflammation in various parts of the body, especially the skin, joints, blood, and kidneys. The immune system loses its ability to tell the difference between foreign substances and its own cells and tissues, then makes antibodies directed against itself. Lupus can be difficult to diagnose as the symptoms can be intermittent and can mimic other illnesses.

Nearly two million Americans have been diagnosed with lupus, making it more prevalent than AIDs, cerebral palsy, multiple sclerosis, sickle-cell anemia, and cystic fibrosis combined. Although lupus can occur in either sex and at any age, lupus strikes adult women 10-15 times more frequently than adult men. Lupus is more prevalent in African-Americans, Latinos, Native Americans, and Asians. Although lupus ranges from mild to life-threatening and thousands of Americans die with lupus each year, the majority of cases can be controlled with proper treatment.

Systemic Lupus Erythematosus, Third Edition has been updated from a very successful book previously offered from another publisher. Accepted as a classic reference in the area of SLE, the previous two editions cover the basic and clinical aspects of the disease. This Third Edition includes new chapters and expanded coverage of central nervous system disease and lupus, renal function, lupus and pregnancy, and experimental therapies. It presents comprehensive, current coverage of basic models of etiology and pathogenesis, and includes a complete catalog of autoantibodiesproduced, clinical manifestations, and therapeutic approaches.

Product Details

ISBN-13: 9780080961712
Publisher: Elsevier Science
Publication date: 10/29/2010
Sold by: Barnes & Noble
Format: NOOK Book
Pages: 1154
File size: 55 MB
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No other Lupus text provides such an amalgam of basic research and clinical practice of the highest caliber

Table of Contents

Section I.Pathogenesis
1.Autoimmunity and Autoimmune Diseases like Systemic Lupus Erythematosus
2.Overview of Cellular Immune Function in Systemic Lupus Erythematosus
3.Etiopathogenesis of Systemic Lupus Erythematosus: The Itineraries of Three Troikas
4.MHC Class II and Non-MHC Genes in the Pathogenesis of Systemic Lupus Erythematosus
5.Genetic Susceptibility and Class III Complement Genes
6.Complement Deficiency and Systemic Lupus Erythematosus
7.Gender and Age in Systemic Lupus Erythematosus
Section II.Animal Models
8.Genes and Genetics of Murine Systemic Lupus Erythematosus
9.Systemic Lupus Erythematosus in Domestic Animals
Section III.Antiantibodies and Antigens
10.Anti-DNA Antibodies: Structure, Assembly and Diversity
11.Anticytoplasmic Antibodies in SLE: Antibodies to Cytoplasmic Antigens
12.Antihistone Antibodies
13.Antibodies to Non-Histone Agents in Systemic Lupus Erythematosus
14.Immune Complexes
15.Origins of Antinuclear Antibodies
Section IV.Clinical Approach to Diagnosis
16.The Clinical Presentation of Systemic Lupus Erythematosus in Adults
17.Neonatal Lupus Syndromes
18.Systemic Lupus Erythematosus in Childhood
19.Imaging of Systemic Lupus Erythematosus: State of the Art
20.Monitoring Patients and Systemic Lupus Erythematosus
21.Laboratory Evaluation of Patients with Systemic Lupus Erythematosus
22.Systemic Lupus Erythematosus Pregnancy
23.Epidemiology of Systemic Lupus Erythematosus
24.Overlap Syndromes: Mixed Connective Tissue Disease and Sjogren's Syndrome
25.Systemic Lupus Erythematosus and Fibromyalgia
Section V.Organs Affected by Systemic Lupus Erythematosus
Nervous System
26.Neuropsychiatric Systemic Lupus Erythematosus
27.Psychiatric Aspects of Systemic Lupus Erythematosus
28.Cognitive Dysfunction in Systemic Lupus Erythematosus
29.Systemic Lupus Erythematosus and the Skin
30.Systemic Lupus Erythematosus and the Kidney
31.Cardiovascular Systemic Lupus Erythematosus
32.Systemic Lupus Erythematosus and the Cardiovascular System: Vasculitis
33.Systemic Lupus Erythematosus and the Lung
34.Nonhepatic Gastrointestinal Manifestations of Systemic Lupus Erythematosus
35.Hepatic Disease and Systemic Lupus Erythematosus: Coincidence or Converence
36.The Cellular Hematology of Systemic Lupus Erythematosus
37.Articular Manifestations of Systemic Lupus Erythematosus
38.Osteoporosis and Metabolic Bone Disease in Systemic Lupus Erythematosus
Section VI.Specific Syndromes antiphospholipid Syndrome
39.Immunology of Antiphospholipid Antibodies and Co-factors
40.The Clinical Aspects of the Antiphospholipid Syndrome
41.The Catastrophic Antiphospholipid Syndrome
42.Hematology: Coagulation Problems
43.The Antiphospholipid Syndrome: Pathogenesis and Implications for Systemic Lupus Erythematosus
Drug-Induced Systemic Lupus Erythematosus
44.Pathophysiology of Drug-Induced Systemic Lupus Erythematosus
45.Drug and Environmental Systemic Lupus Erythematosus: Clinical Manifestations and Differences
Section VII.Therapy of Systemic Lupus Erythematosus
46.Corticosteroid Use in Systemic Lupus Erythematosus
47.Antimalarials and Immunosuppresive Therapies
48.Unproven and Experimental Therapies

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