Pub. Date:
Springer Japan
Systems Biology: The Challenge of Complexity / Edition 1

Systems Biology: The Challenge of Complexity / Edition 1

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Biological signaling pathways dynamically interact with one another to form complex information networks intracellularly, intercellularly, and eventually at the level of the organism. Biology and medicine have conventionally focused on identification and characterization of functional elements in biological signaling pathways. Recently, research in this field has pursued a new approach, systems biology, to understand the dynamics, complexity, and physiological functions of the biological signaling networks. Instead of reductionistic analyses or large-scale studies of biomolecules piece by piece, systems biology emphasizes the need for interdisciplinary methods and analysis of the regulation and operation of information networks at the systems level. The contributors to this book are leading researchers in the rising field of systems biology. Readers will find not only the most recent advances in research, but also the latest information about interdisciplinary methods and related topics.

Product Details

ISBN-13: 9784431998587
Publisher: Springer Japan
Publication date: 12/22/2010
Edition description: Softcover reprint of hardcover 1st ed. 2009
Pages: 246
Product dimensions: 6.10(w) x 9.25(h) x 0.36(d)

Table of Contents

Preface v

Contributors xi

Part I Dynamics and Complexity of Intercellular Networks

Integrative Synaptic Mechanisms of the Neural Network Shigetada Nakanishi 3

The Molecular and Cellular Design of Networks in Motion Sten Grillner Peter Wallen Russell Hill 11

Bacterial Complexity: More Is Different on All Levels Eshel Ben-Jacob 25

How Animals Get Their Skin Patterns: Fish Pigment Pattern as a Live Turing Wave Shigeru Kondo 37

Characterization and Application of Natural Light-Sensitive Proteins Jens Looser Georg Nagel 47

Systems Biology of Mammalian Circadian Clocks Hiroki R. Ueda 57

Toward Understanding How the Immune System Establishes a Diverse Yet Self-Tolerant T-Cell Repertoire: Stepwise Roles of Thymic Microenvironments Takeshi Nitta Yousuke Takahama 71

The Mechanisms of Motor Programming for Learned Vocalization in Songbirds Hisataka Fujimoto Taku Hasegawa Ryosuke Matsui Kentaro Abe Dai Watanabe 83

Dynamic Model of the Basal Ganglia Functions and Movement Disorders Atsushi Nambu 91

Part II Integrative Mechanism of Intracellular Information Networks

A Posttranslational Chemical Circadian Oscillator in Cyanobacteria Hideo Iwasaki 101

The Apoptotic Signaling Network Dynamically Interprets the Outputs of Individual Signaling Pathways in an Early Analog and Late Digital Manner Kevin A. Janes H. Christian Reinhardt Michael B. Yaffe 111

Specific Features of Transient Ras and Sustained Rap1 Activation Yu-ichi Ozaki Shinsuke Uda Shinya Kuroda 121

Control and Alteration of Protein Traffic in the Cell Toshiya Endo 129

Plant Functional Genomics Based on Integration of Metabolomics and Transcriptomics: Toward Plant Systems Biology Kazuki Saito135

A Possible Role of Homeostasis Between Monomeric and Filamentous Actin in Filament Nucleation Revealed by Pharmacokinetic Modeling Naoki Watanabe Chiharu Higashida 143

Molecules, Networks, and Memory Upinder S. Bhalla 151

Systems Biology Meets Single-Cell Physiology: Role of a Positive-Feedback Signal Transduction Network in Cerebellar Long-Term Synaptic Depression Keiko Tanaka George J. Augustine 159

Computational Models of Cerebellar Long-Term Memory Hideaki Ogasawara Mitsuo Kawato 169

Biogenesis and Function Mechanisms of Micro-RNAs and Their Role as Oncogenes and Tumor Suppressors Soken Tsuchiya Kazuya Terasawa Ryo Kunimoto Yasushi Okuno Fumiaki Sato Kazuharu Shimizu Gozoh Tsujimoto 183

Part III Dysfunction of Information Networks and Related Diseases

The Pathogenetic Significance of Deregulated Transcription Factors in Hematological Malignancies Masahiro Nakagawa Susumu Goyama Motoshi Ichikawa Mineo Kurokawa 193

Ultradian Oscillation Networks in Somite Segmentation and Other Biological Events Yasutaka Niwa Hiromi Shimojo Ryoichiro Kageyama 199

The Cellular Basis of Dictyostelium Morphogenesis Cornelis J. Weijer 209

Metabolic Information Highway: Interorgan Metabolic Communication Via the Autonomic Nervous System Hideki Katagiri 221

Involvement of the CCR4-NOT Deadenylase Complex in the Control of Cell Growth Masahiro Morita Kentaro Ito Toru Suzuki Tadashi Yamamoto 229

Reconstruction of Nuclear Reprogramming by Defined Factors Shinya Yamanaka 239

Index 243

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