T Cell Activation

T Cell Activation

by Jennifer E. Smith-Garvin

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Overview

T Cell Activation by Jennifer E. Smith-Garvin, Gary A. Koretzky, Martha S. Jordan

2009 marked the 25th anniversary of the first Annual Review of Immunology article to describe features of the T cell antigen receptor (TCR). In celebration of this anniversary, we begin with a brief introduction outlining the chronology of the earliest studies that established the basic paradigm for how the engaged TCR transduces its signals. This review continues with a description of the current state of our understanding of TCR signaling, as well as a summary of recent findings examining other key aspects of T cell activation, including cross talk between the TCR and integrins, the role of costimulatory molecules, and how signals may negatively regulate T cell function.

Product Details

BN ID: 2940013207523
Publisher: Annual Reviews
Publication date: 10/24/2011
Series: Annual Review of Immunology , #27
Sold by: Barnes & Noble
Format: NOOK Book
Pages: 28
File size: 6 MB

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