Tactics is the art of combining the action of troops or the proper means of different arms with the object of obtaining the maximum success at combat. Strategy is the art of combining the action of aB the military forces with a view to victory. This work, wh ich publishes the communications at the Annual General Meeting of the EORTC, wh ich was held in Paris in lune 1976, was devoted to tactics and to the therapeutic strategy with a view to the recovery of cancer patients. Table of Contents v Preface . I. Tactics G. MATHE: Tactics in Cancer Treatment: Introduction 1 1. Surgery F. ECONOMIDES and M. BRULEy-RosSET: Effects of the Removal of the Regional Lymph Nodes on the Survival of Mice Bearing B16 Melanoma or EAkR Lymphosarcoma . 2 U. VERONESI: Regional Lymph Node Dissection in Melanoma of the Limbs. Stage I-A Cooperative International Trial . 8 2. Chemotherapy G. MATHE, O. HALLE-PANNENKO, and C. BOURUT: Effectiveness of Murine Leukemia Chemotherapy According to the Immune State: Reconsideration of Correlations Between Chemotherapy, Tumour Cell Killing, and Survival Time 9 A. J. S. DAVIES: C!"temotherapy of Tumours in Immuno-deprived Mice 13 P. POUILLART, G. MATHE, T. PALANGJE, J. LHERITIER, M. PmSSON, P. HUGUENIN, H. GAUTIER, P. MORIN, and R. PARROT: Treatment of Malignant Gliomas and Brain Metastases in Adults Using a Combination of Adriamycin, VM 26 and CCNU- Results of Type 11 Trial . 17 3. lmmunotherapy L. OLSSON: Immunologie and Cytokinetic Parameters of BCG-induced Growth Control of a Murine Leukemia .
Table of ContentsI. Tactics.- Tactics in Cancer Treatment: Introduction.- 1. Surgery.- Effects of the Removal of the Regional Lymph Nodes on the Survival of Mice Bearing B16 Melanoma or EAkR Lymphosarcoma.- Regional Lymph Node Dissection in Melanoma of the Limbs. Stage IA Cooperative International Trial.- 2. Chemotherapy.- Effectiveness of Murine Leukemia Chemotherapy According to the Immune State: Reconsideration of Correlations Between Chemotherapy, Tumour Cell Killing, and Survival Time.- Chemotherapy of Tumours in Immuno-deprived Mice.- Treatment of Malignant Gliomas and Brain Metastases in Adults Using a Combination of Adriamycin, VM 26 and CCNUResults of Type II Trial.- 3. Immunotherapy.- Immunologic and Cytokinetic Parameters of BCG-induced Growth Control of a Murine Leukemia.- 4. Monitoring.- Biochemical Aids to Cancer Management.- Laboratory Testing for Cancer.- II. General Strategy.- The Strategy of Cancer Treatment: Introduction.- 1. Leukemias and Hematosarcomas.- Treatment of Murine EAkR Lymphosarcoma by Surgery Combined With Systemic or Local Active BCG Immunotherapy Applied Repeatedly.- Interspersion of Cyclophosphamide and BCG in the Treatment of L1210 Leukemia and Lewis Tumor.- Results in Children of Acute Lymphoid Leukemia: Protocol ICIG-ALL 9 Consisting of Chemotherapy for Only 9 Months Followed by Active Immunotherapy.- Active Immunotherapy in Leukemia with Neuraminidase-Modified Leukemic Cells.- Chemotherapy and Immunotherapy Interspersion: Clinical Studies in Acute Myeloblastic Leukemia.- Androgens and Long-Term Complete Remission in Acute Granulopoietic Leukemias.- Treatment by Radiophosphorus Versus Busulfan in Polycythemia Vera: A Randomized Trial. E.O.R.T.C. “Leukemias and Hematosarcomas” Group.- The Strategy of Treatment of Hodgkin’s Disease.- 2. Solid Tumors.- Limb Preservation in Osteogenic Sarcoma: A Preliminary Report.- Breast Cancer: Changing Strategy for Treatment.- Radiotherapy in the Therapeutic Strategy to Breast Cancer.- Adjuvant Combination Chemotherapy in Primary Mammary Carcinoma: The CMF Program.- Chemo Immunotherapy of Advanced Breast Cancer With BCG.- Trial of BCG Immunotherapy in the Treatment of Resectable Squamous Cell Carcinoma of the Bronchus (Stages I and II).- Postoperative Nonspecific Immunotherapy in Primary Bronchogenic Carcinoma.- The Strategy of Cancer Treatment: Testicular Carcinoma.- Strategy of Testis Cancer Treatment.- The Combination of Surgery, Radiotherapy, and Chemotherapy in the Treatment of Gastric Cancer.- Initial Therapeutic Strategies Applied to Treatment of Common Epithelial Cancers of the Ovary (Stages IIb-III). “Ovary” Working Party of the E.O.R.T.C.- Strategy and Tactics in Prostatic Cancer.- Treatment of Trophoblastic Tumours.- The Management of Musculoskeletal Tumours.- The Management of Wilms’ Tumor.- Present Strategy of Treatment of Neuroblastoma.- Surgery in the Treatment of Pulmonary Metastases.- Treatment of Cervical Lymph Node Metastases From Carcinomas of the Upper Respiratory and Digestive Tracts.