This comprehensive account of hereditary acetylation in humans and animals is based on the premise that varied individual responses to drugs, chemicals, and carcinogens are profoundly influenced by genetic factors. Acetylation, the mechanism by which the body disposes of many chemicals encountered in everyday life, presents a unique example of how a multiplicity of genetically determined differences in drug response can arise from a single metabolic theme, and of how the understanding of a pharmacogenetic trait can be used to prevent human illness of environmental origin. This monograph assesses the role of drug acetylation as a genetic factor capable of altering susceptibility to therapeutic drug effects and toxicity, and provides a unified view of the genetic and biochemical features of acetylation polymorphisms.
Table of Contents
PART I: Acetylation Polymorphisms, Discovery, and Biological Basis