The Acetylator Genes and Drug Response

The Acetylator Genes and Drug Response

by Wendell W. Weber



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The Acetylator Genes and Drug Response by Wendell W. Weber

This comprehensive account of hereditary acetylation in humans and animals is based on the premise that varied individual responses to drugs, chemicals, and carcinogens are profoundly influenced by genetic factors. Acetylation, the mechanism by which the body disposes of many chemicals encountered in everyday life, presents a unique example of how a multiplicity of genetically determined differences in drug response can arise from a single metabolic theme, and of how the understanding of a pharmacogenetic trait can be used to prevent human illness of environmental origin. This monograph assesses the role of drug acetylation as a genetic factor capable of altering susceptibility to therapeutic drug effects and toxicity, and provides a unified view of the genetic and biochemical features of acetylation polymorphisms.

Product Details

ISBN-13: 9780195039320
Publisher: Oxford University Press, USA
Publication date: 11/19/1987
Series: Oxford Monographs on Medical Genetics Series
Pages: 270
Product dimensions: 6.38(w) x 9.50(h) x 0.93(d)

Table of Contents

PART I: Acetylation Polymorphisms, Discovery, and Biological Basis

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