the GABA increase takes place and (2) the area of the brain that may mediate the anticonvulsant Investigation of the physiology, biochemistry, activity. Three compounds that increase brain pharmacology and anatomy of GAB A and GABA GABA by distinct mechanisms were used in these containing neural systems, continues to reveal the studies: di-n-propylacetate (DPA, sodium val rich complexities associated with this neuroactive proate, Depakene(R)), amino-oxyacetic acid amino acid (see recent symposia 1,2,3). Advances (AOAA) and y-vinyl GABA (GVG). in the pharmacology of GABA-mimetic agents In the next sections, the metabolism of GABA have resulted in the development of compounds and a brief historical account of the relationship that can selectively activate GABA receptors (4,5, between GABA and anticonvulsant activity are 6, 7), inhibit the synthetic and degradative enzymes outlined followed by a discussion ofthe biochemical for GABA (8, 9) or affect the neuronal and glial and pharmacological effects of the three drugs. In uptake processes for GABA (10, 11). This has particular, the literature pertaining to the suppres already had a significant impact on our under sion of seizures and the correlation between anti standing of the role of GABA in convulsions and a convulsant action and increases in brain G ABA will range of other CNS functions including feeding be examined. (12), cardiovascular control (13), motor activity (14) and release of pituitary hormones (15). Before 1.
|Series:||Developments in Molecular and Cellular Biochemistry , #1|
|Product dimensions:||8.27(w) x 11.02(h) x 0.03(d)|
Table of Contentsto ‘Developments in molecular and cellular biochemistry’.- 1. Hippocampal glutamate receptors.- 2. Enzymatic synthesis and function of folypolyglutamates.- 3. ?-Aminolevulinic acid and amino acid neurotransmitters.- 4. ?-Glutamylamine cyclotransferase.- 5. GABA and the enteric nervous system.- 6. Post-translational carboxylation of preprothrombin.- 7. Glutamate and aspartate agonists structurally related to ibotenic acid.- 8. GABA agonists.- 9. Pharmacology of GABA-mediated inhibition of spinal cord neurons in vivo and in primary dissociated cell culture.- 10. Molecular characteristics of glutamate receptors in the mammalian brain.- 11. Pyroglutamic acid.- 12. Gamma-carboxyglumatic acid.- 13. Folypoly-?-glutamate synthesis by bacteria and mammalian cells.- 14. Immunocytochemical and autoradiographic localization of GABA system in the vertebrate retina.- 15. L-glutamate transport in renal plasma membrane vesicles.- 16. Glutamate as a precursor of GABA in rat brain and peripheral tissues.- 17. The GABA postsynaptic membrane receptor-ionophore complex.- 18. The stimulation of ion fluxes in brain slices by glutamate and other excitatory amino acids.- 19. Alterations of central GABAergic activity in neurologic and psychiatric disorders: evaluation through measurements of GABA and GAD activity in cerebrospinal fluid.- 20. Cellular compartments of GABA in brain and their relationship to anticonvulsant activity.- 21. Pteroylpolyglutamates.- 22. Glutamate receptor binding in insects and mammals.- 23. ?-Glutamyl transpeptidase: catalytic, structural and functional aspects.- 24. Utilization of GABA in Substantia Nigra.