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This volume comprises the papers from the 19th Kumamoto Medical Bioscience Symposium held in Kumamoto, Japan between 7 and 8 November 2002. The papers focus on the frontiers of research related to the cellular, molecular and genetic aspects of the biological response to planned and unplanned injuries. Planned (operation, etc) and unplanned (trauma, infection, etc.) injuries may disturb the homeostasis of living organisms that, in turn, create several biological responses to maintain their homeostasis. The year 2002 was the 50th anniversary of the discovery of the double-helix structure of DNA. Using the sophisticated molecular biological techniques, numerous cytokines have been cloned as mediators of biological response since the late 1970s. Such discoveries have provoked a dramatic progression in the research in this field. The Symposium encouraged the exchange of current topics regarding such biological responses from around the world in order to make further advances in controlling them.
Table of Contents
1. Plenary lectures.
The community of the shelf (T.G. Buchman). Regulation of innate immune response by Stat proteins during septic peritonitis (A. Matsukawa). High-recision analysis of gene expression in whole blood: assessment of patient status and response to therapy (J.C. Cheronis). Regulation of inflammatory responses by activated protein C (K. Okajima). Cellular, molecular and sexual dimorphic response to trauma-hemorrhage (M.A. Choudry et al.). Clinical aspect of hypercytokinemia-induced pathophysiology in critical care (H. Hirasawa et al.). Significance of trypsin inhibitor gene mutation in the predisposition to pancreatitis (M. Hirota et al.). Molecular and genetic mechanisms of acute and chronic pancreatitis (D.C. Whitcomb). Nutrition and phagocyte intracellular signal transduction (H. Saito, W. Kang, S. Ikeda). Initial and delayed inflammatory and counter-inflammatory mediator patterns following severe injury (E. Faist).
2. Cytokine reaction/polymorphism.
Inhibition of tumor necrosis factor-á production by urinary trypsin inhibitor (H. Isobe et al.). Increase in plasma IL-18 in patients with hepatic failure reflects the decreased hepatic metabolism (M. Shibata et al.). Alteration of the cytokine-related gene expression levels in lymphocytes observed in terminally injured patients estimated by the DNA chip technology (T. Tarui et al.). Gabexate mesilate, a synthetic protease inhibitor, inhibits lipopolysaccharide-induced tumor necrosis factor-á production by inhibiting activation of both nuclear factor-êB and activator protein-1 in human monocytes (M. Yuksel, K. Okajima, M. Uchiba). Genetic polymorphisms in the promoter region of interleukin-8 (S. Fujishima et al.). Cytokine gene polymorphisms predict acute rejection following renal transplantation (L. Yang, Y. Liu).
3. Molecular detection of cancer cells.
Peritoneal metastasis after operation for non-serosa-invasive gastric carcinoma and a prophylactic strategy for peritoneal dissemination (T. Marutsuka et al.). Establishment of a rapid procedure for one-step real-time reverse transcription-polymerase chain reaction in combination with automated mRNA extraction: a clinical application to intraoperative molecular diagnosis of cancer cells (N. Hayashi et al.). Molecular detection of occult cancer cells in the patients with liver tumors treated by local ablation therapy (T. Maeda et al.).
4. Surgical insults.
Video-assisted minithoracotomy vs conventional open thoracotomy: clinical evaluation of video-assisted thoracic surgery for non-small cell lung cancer (T. Tashima et al.). Changes of serum levels of vascular endothelial growth factor following major surgical injury (R. Futami et al.). Changes of interleukin 6 and soluble IL-6 receptor levels after surgery (K. Sakamoto et al.). Accelerated cytokine responses of elderly patients result in significant increase of systemic inflammatory response syndrome and postoperative complications following gastrointestinal surgery (T. Beppu et al.). Perforation of Meckel's diverticulum in a neonate delivered to a mother with hyperthyroidism (S. Okazaki et al.).
Contribution of IL-18 and its related cytokines on the development of hepatic dysfunction in non-biliary acute pancreatitis (M. Shibata et al.). Interleukin-18 levels reflect the severity of acute pancreatitis (H. Nakae et al.). The effect of TNF-á converting enzyme inhibitor on cytokine response in acute pancreatitis (K. Maeda et al.). Dynamic aspects of granulocyte activation in acute pancreatitis (Y. Kimura et al.). Cytokine storm in acute pancreatitis: influence of inflammatory attack and arterial infusion therapy (M. Sugimoto et al.). Endothelin is involved in pancreatic and intestinal ischemia during severe acute pancreatitis (K. Inoue et al.). Functional analysis of pancreatic secretory trypsin inhibitor protein with amino acid substitution (K. Kuwata, M. Hirota, M. Ogawa). Generation of pancreatic secretory trypsin inhibitor gene knockout mice (M. Omuraya et al.).
Prolonged survival of rat hepatic allografts after pretransplant intraportal administration of recipient blood to the donor (F. Wang et al.). Study of the protective effect of zinc: a potent HSP inducer during liver cold preservation in rat (Y. Cheng et al.). Simultaneous pancreas-kidney transplantation at the china medical university: report of 13 cases (Y. Liu et al.). Hepatic artery reconstruction in orthotopic liver transplant (J. Liang et al.). Study of cytomegalovirus infection in renal transplant recipients (Y. Meng, Y. Liu). Isolation and protective effect in UW solution of human hepatocytes during cold storage (G. Li, Y. Liu, J. Liang).
Surfactant protein A and D levels in patients with septic ARDS (H. Nakae et al.). The TH1/TH2 ratio in the patients with diminished expression of HLA-DR on monocytes1 (Y. Imamura et al.). Biophysics-induced tissue regeneration. A pilot study using "delta-S" entropy variation system on burns sequelae and keloids (G. Marineo et al.).
8. Neutrophil/endothelial cell/NO.
A pulmonary metastatic model of human non-small cell lung carcinoma cells in SCID mice (E. Tanaka et al.). Induction of neutrophil elastase by TNF-á in human cancer cell lines (S. Ishikawa et al.). Inhibition by antithrombin of cytokine-induced endothelial cell activation in vitro (M. Uchiba et al.). Protective function of nitric oxide in murine Salmonella infection (M.S. Alam, T. Akaike, H. Maeda). Heme oxygenase and nitric oxide synthase on tumor growth (K. Doi et al.).
9. Signal transduction/DNA synthesis.
Pharmacological difference in muscarinic receptors between circular and longitudinal muscle cells of murine small intestine (D. Sato, K. Nishi, M. Ogawa). GANP DNA primase associated with MCM3 and DNA synthesis (S. Tomiyasu et al.).
Atrophic/metaplastic changes of gastric mucosa: a preliminary interventional trial comparing different antioxidant supplements (F. Marotta et al.). Proposal of genetic pathways of 'de novo' colorectal carcinomas (K. Shiomori et al.). Immunohistochemical expression of SKALP/elafin in squamous cell carcinoma of human lung and esophagus (N. Yoshida et al.).
11. Metastasis/invasion of cancer cells.
Analysis of the signal transduction pathway in related to invasion and metastasis in pancreatic cancer (H. Egami et al.). Correlation of extracellular signal-regulated kinase 2 expression and the cell disscociation induced by dissociation factor (DF) in pancreatic cancer cells (X. Tan et al.). Mechanism of surgical oncotaxis and its regulation (J. Hihara et al.). Type IV collagen á chains in colon cancer (Y. Hiki et al.).
12. Cancer biology/treatment.
Human carcinoma cells express IL-8 and IL-8 receptor: their role and regulation in cancer biology (T. Ishiko et al.). The signal of proteinase-activated receptor-2 plays an important role in pancreatic cancer progression (O. Ikeda et al.). Effects of far infrared ray on Hela cells and WI-38 cells (Y. Hamada et al.). Identification of cancer antigens by SEREX (T. Nakatsura et al.). Group II phospholipase A2 is increased in peritoneal and pleural effusions in patients with various cancers (T. Abe et al.). Biological significance of the production of membrane-associated phospholipase A2 in human gastric cancer (H. Ohmachi et al.). Expression of group II phospholipase A2 in malignant and nonmalignant human hepatocytes (S. Ohshima et al.). Possible relationship between the expression of membrane-associated phospholipase A2 and the proliferation of interstitial tissue in human pancreatic cancer (H. Kiyohara et al.). Artificial neurons in oncological pain: the potential of Scrambler Therapy to modify a biological information (G. Marineo et al.). Proposal of the optimal and practical therapeutic strategy for gastric cancer (S. Shimada et al.).