The calcitonin gene-related peptide family: form, function and future perspectives

The calcitonin gene-related peptide family: form, function and future perspectives


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The calcitonin gene-related peptide family: form, function and future perspectives by Deborah L. Hay

This book contains a comprehensive series of reviews on the calcitonin generelated peptide (CCRP) family of peptides. This family of peptide hormones has a diverse and constantly expanding range of important physiologic functions, including regulation of blood calcium, vascular tension, feeding behavior and pain recognition.

This volume includes chapters on:

The adrenomedullin peptides and signaling

Ligand binding and activation of the CGRP receptor

Understanding amylin receptors

The CGRP-receptor component protein

The Calcitonin peptide family

Genetic regulation of CGRP

Vascular actions of CGRP and adrenomedullin

Intermedin/adrenomedullin function

CGRP and adrenomedullin as pain-related peptides

Amylinergic control of ingestive behavior

Calcitonin receptors

This book discusses their receptors, physiological and pathophysiological functions and potential as clinical targets. It will appeal to researchers who study any of these peptides and those with an interest in migraine therapy due to the involvement of CGRP in this disorder. The book is unique because it brings together research on the whole peptide family for the first time in several years. It will be a useful reference volume for researchers in this area. This book will also appeal to researchers in the broader field of bioactive peptides.

Product Details

ISBN-13: 9789400791800
Publisher: Springer Netherlands
Publication date: 11/01/2014
Edition description: 2010
Pages: 236
Product dimensions: 6.10(w) x 9.25(h) x 0.02(d)

Table of Contents

1 Molecular and Functional Evolution of the Adrenomedullin Family in Vertebrates: What Do Fish Studies Tell Us? Yoshio Takei Maho Ogoshi Marty K. S. Wong Shigenori Nobata 1

2 Ligand Binding and Activation of the CGRP Receptor James Barwell John Simms Alex Conner Debbie Hay Mark Wheatley David Poyner 23

3 Understanding Amylin Receptors Rasmus Just John Simms Sebastian G.B. Fumess Arthur Christopoulos Patrick M. Sexton 41

4 The CGRP-Receptor Component Protein: A Regulator CLR Signaling Ian Dickerson 59

5 The Calcitonin Peptide Family: What Can We Learn from Receptor Knock Out and Transgenic Mice Walter Born Jan A. Fischer 75

6 Gene Targeted Mouse Models of Adrenomedullin Signaling Mahita Kadmiel Kathleen M. Caron 87

7 Genetic Regulation of CGRP and Its Actions Ki-Youb Park Andrew F. Russo 97

8 Vascular Actions of CGRP and Adrenomedullin: Mechanisms and Potential Contribution to Inflammation in the Cutaneous Microvasculature Gabor Pozsgai Lihuan Liang Susan D. Brain 115

9 Insights into the Function of Intermedin/Adrenomedullin 2 Chia Lin Chang Sheau Yu Teddy Hsu 131

10 CGRP and Adrenomedullin as Pain-Related Peptides Weiya Ma Jean-Guy Chabot Ara Schorscher-Petcu Yinguo Hong Zhiyong Wang Remi Quirion 151

11 Amylinergic Control of Ingestive Behaviour Thomas A. Lutz 173

12 CGRP Receptor Antagonists for Migraine: Challenges and Promises Christopher A. Salvatore Stefanie A. Kane 185

13 Calcitonin Receptor Expression in Embryonic, Foetal and Adult Tissues: Developmental and Pathophysiological Implications P.J. Wookey A. Zulli C. Lo D.L. Hare A.P. Schwarer LA. Darby A.Y. Leung 199

14 Conclusions and Future Perspectives Debbie L. Hay 235

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