The Carbonic Anhydrases: New Horizons

The Carbonic Anhydrases: New Horizons

Paperback(Softcover reprint of the original 1st ed. 2000)

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Product Details

ISBN-13: 9783034895705
Publisher: Birkh�user Basel
Publication date: 11/05/2012
Series: Experientia Supplementum , #90
Edition description: Softcover reprint of the original 1st ed. 2000
Pages: 619
Product dimensions: 6.10(w) x 9.25(h) x 0.05(d)

Table of Contents

Exordium: Remarks on the discovery of carbonic anhydrase.- to the carbonic anhydrases.- Evolution and distribution of the carbonic anhydrase gene families.- An overview of the distribution and function of carbonic anhydrase isozymes in mammals.- The membrane carbonic anhydrases: from CO2transport to tumour markers.- Carbonic anhydrase (CA)-related proteins (CA-RPs), and transmembrane proteins with CA or CA-RP domains.- Regulation of the CA 1, CA 2 and CA 3 genes.- Use of carbonic anhydrase II-deficient mice in uncovering the cellular location of membrane-associated isoforms.- X-ray crystallographic studies of mammalian carbonic anhydrase isozymes.- The catalytic mechanism of mammalian carbonic anhydrases.- Activation of carbonic anhydrase isozymes.- Active-site engineering of carbonic anhydrase and its application to biosensors.- Folding and stability of human carbonic anhydrase II.- Membrane transport and provision of substrates for carbonic anhydrase in vertebrates.- Respiratory and renal roles of carbonic anhydrase in gas exchange and acid-base regulation.- The roles of carbonic anhydrase in metabolism, cell growth and cancer in animals.- The roles of carbonic anhydrase in gustation, olefaction and chemical irritation.- Carbonic anhydrases in striated muscle.- Inherited deficiencies and activity variants of the mammalian carbonic anhydrases.- Carbonic anhydrase inhibition in ophthalmology: Carbonic anhydrase in cornea, lens, retina and lacrimal gland.- Carbonic anhydrase inhibition in ophthalmology: Aqueous humour secretion and development of sulphonamide inhibitors.- The design of new carbonic anhydrase inhibitors.- Roles of carbonic anhydrases in the alimentary tract.- Carbonic anhydrases in the nervous system.- Carbonic anhydrases in calcified tissues.- Carbonic anhydrases of higher plants: an overview.- Plant carbonic anhydrases: structure and mechanism.- Algal carbonic anhydrase.- Bacterial carbonic anhydrases.- Keeping pace with a fast enzyme: steps and missteps.- Carbonic anhydrase research: A clinical perspective, past and future.

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