After decades of marriage, motherhood, and grandmotherhood, Cat Caliban has become Cincinnati's newest, oldest funniest detective-in-training. After all, suspicion is second nature to any woman who's raised three kids. So she sells her suburban house, buys an apartment building in a "transitional" neighborhood, and begins training to be a detective. She's barely had time to settle in, though, before her first case appears in the form of a dead homeless woman in the upstairs apartment. Three other cases follow in quick succession, and Cat investigates them with a colorful cast of housemates, neighborhood hangers-on, three cats, and a beagle puppy.