The Delta Receptor spans current research in delta receptor biology, pharmacology, physiology, and chemistry to identify, advance, and inspire the development of novel drug candidates. It demonstrates the potential significance and impact of the delta receptor in the therapy and treatment of medical conditions such as pain, gastrointestinal disorders, bladder dysfunction, and depression, as well as heart attack prevention. This reference examines the pathophysiological functions and mechanisms of receptor-selective drugs. Documenting key advances in the field, The Delta Receptor represents the most comprehensive and up-to-date studies on receptor applications currently available.
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Table of ContentsThe Delta Receptor: History of Delta Opioid Receptors, Wen-Jen Chang; Cloning of Delta Opioid Receptors, Arnaud Lacoste and Christopher J. Evans Cloning and Expression of the Human Delta Opioid Receptor, Richard J. Knapp, Ewa Malatynska, Eva V. Varga, William R. Roeske, and Henry I. Yamamura; In Vitro and In Vivo Mutagenesis - Insights into Delta Receptor Structure and Function, F.M. Dicaillot and Brigiitte L. Kieffer; Delta Opioid Receptor Signaling and Trafficking, P.Y. Law; Delta Opioid Receptors and G Proteins, Mary J. Clark and John R. Traynor; Transcriptional Regulation of Delta Opioid Receptor, Gene Ping Sun and Horace Loh. Delta Ligands: Benzhydrylpiperazines as Nonpeptidic Delta Opioid Receptor Ligands, Michael J. Bishop and Robert W. McNutt; Delta-Selective Ligands Related to Naltrindole. D.J. Daniels and P.S. Portoghese; Endogenous Peptides for Delta Opioid Receptors and Analogues, Victor J. Hruby and Henry I. Mosberg; Deltorphins, Lucia Negri and Elisa Giannini; Opioid Peptide--Derived Delta Antagonists, Inverse Agonists and Mixed Mu Agonists/Delta Antagonists. Peter W. Schiller; Inverse Agonism at the Delta Opioid Receptors, Eva V. Varga, Keiko Hosohata, Yoshioko Hosohata, Jennifer Tsang, Thomas Burkey, Josue Alfaro-Lopez, Xuejun Tang, Victor R. Hruby, William R. Roeske and Henry I. Yamamura; Mixed Opioid Receptor Agonists as a New Class of Agents for the Treatment of Moderate-to-Severe Pain, Peter J. Gengo and Kwen-Jen Chang; Biphalin - A Multireceptor Opioid Ligand Binding and Activity of Opioid Ligands at the Cloned Human Delta, Mu and Kappa Receptors Andrez W. Lipkowski, Daniel B. Carr, Iwona Bonney and Aleksandra Misicka Kemal Payza; Inhibitors of Enkephalin-Inactivating Enzymes and Delta Opioid Responses, Bernard P. Roques and Florence Noble. Pharmacology And Physiology: Delta Opioid Receptor Subtypes and Pain Modulation, Michael H. Ossipov, Josephine Lai, Todd W. Vanderah and Frank Porreca; Delta Opioid Receptor-Mediated Antinociception/Analgesia Minoru Narita and Tsutomu Suzuki; Antidepressant-like Effects of Delta Opioid Receptor Agonists, Emily M. Jutkiewicz and James H. Woods; Mu-Delta Interactions In Vitro and In Vivo, Richard B. Rothman and Heng Xu; Delta Opioids and Immune Function, Richard J. Weber and Ricardo Gomez-Flores; Delta Opioids and Substance Abuse, S. Stevens Negus; Delta Opioid Receptors in the Gastrointestinal Tract, DeWayne Townsend IV and David R. Brown; Cardioprotection and Delta Opioid Receptors, Garrett J. Gross, Ryan M. Fryer, Hemal H. Patel and Joel J. Schultz; The Delta Opioid Receptor and Brain Pain-Modulating Circuits, Mary M. Heinricher and Howard L. Fields.