The Environmental and Genetic Causes of Autism delves deep into the full body of past and current research to reveal how genetic predispositions and environmental factors can combine to produce the conditions autism and autism spectrum disorders (ASD).
To make this groundbreaking volume, Dr. James Lyons-Weiler combed through the past fifty years of published research on autism, exploring subjects such as genetic variation, mechanisms of neurotoxicity of metals and pesticides, and the central and combined roles of each in causing autism.
Lyons-Weiler provides a major overview of all aspects of the condition of autism, reviews changes in diagnoses and treatments, and explains how genetic information can be used to tailor effective treatments, and sometimes reversals, of the symptoms. He also presents practical forward-looking suggestions on how to design future studies to facilitate the discovery of biomarkers for autism risk and how to classify the full range of autism spectrum disorders.
Autism is considered one of the most mystifying conditions of our day, and alarmed scientists, doctors, politicians, and parents are desperately trying to understand why the condition is escalating. According to the CDC, rates in the United States have risen from an estimated one in two thousand children in 1980, to one in sixty-eight in 2012, and a new National Health Interview Survey shows a rate of one in forty-five. By the time you read this book, that number may have changed yet again.
While most autism researchers focus on either environmental or genetic causes of autism, Lyons-Weiler’s opus demonstrates that to fully understand the condition and to finally put its rate on the decrease, it is essential to pay attention to the science showing how the two classes of factors interact.
|Sold by:||Barnes & Noble|
|File size:||1 MB|
About the Author
Table of Contents
Foreword Richard E. Frye, MD, PhD xiii
Chapter 1 Background and Concepts 5
Chapter 2 Symptoms and Diagnosis of Autism 69
Chapter 3 Evidence of Genetic and Epigenetic Risk Components of Autism and Autism Spectrum Disorder 87
Chapter 4 Speech, Language, and Communication Phenotypes in ASD 116
Chapter 5 Genetic and Environmental Factors that Influence Social Cognitive Skills in ASD 134
Chapter 6 Cognitive Phenotypes in ASD 153
Chapter 7 Repetitive Motor Behaviors and Seizure Phenotypes 159
Chapter 8 Sensory Phenotypes and Sensory Processing Disorder 165
Chapter 9 Immunological Factors in Autism and ASD 169
Chapter 10 Gastrointestinal and Renal Phenotypes in ASD 192
Chapter 11 Neurotoxin-Induced Autoimmune-Mediated Neurological Damage in Autism 200
Chapter 12 Vaccine-Autism Studies Ignored by the CDC 217
Chapter 13 Concepts of Comorbidity in Autism and Autism Research 230
Chapter 14 Study Designs for Meaningful Future Causal Research in Autism 243
Chapter 15 Biological Pathways and Networks Views of Autism 255
Chapter 16 Toward a Multidimensional Matrix Risk Model for Autism 262
Chapter 17 The Logic of Prevention in Autism and Gene-Informed Treatment 273
Chapter 18 Injecting Objective Association and Causal Inference into Clinical Trials, Prevention, Diagnosis, and Treatment of ASD 294
Most Helpful Customer Reviews
This book is a complete paradigm shift, the likes of which I've never seen. After 4 years of research on autism, genetics, immunity and disease, attempting to understand and treat my son's autism, this one book brings it all together. All of the factors contributing to this epidemic are represented here. Documented, assimilated, translated and notated by a brilliant minded scientist. James Lyons-Weiler's background in Molecular Biology, Molecular Evolution, Plant Biology, Biogeography, and Paleontology, and Population Ecology, Classical and Molecular Cytogenetics, Conservation Biology, Population Genetics, and Experimental Design apparently uniquely qualified himself alone to write this definitive work. It does NOT provide the easy answers, but all the right questions, implication and indictment. On a little reading binge, this is my 14th book in the last 2 months relating to autism, infectious disease, immunology... the history and politics. But, this ONE book reveals a depth of study that makes most others look like they're in the sandbox The devil is truly in the details. Even the most exceptional scientific minds will be challenged to assimilate the depth and breadth of this examination in translational research. James Lyons-Weiler has written THE MOST IMPORTANT BOOK IN PEDIATRICS right now and for the foreseeable future. I am only half way in as I read and re-read sections trying to wrap my head around his interpretation of over 3,000 peer reviewed studies. A warning to those without a high capacity for complex scientific analysis, it may not be the first book you should read in understanding the complexity of the 'debate' on autism. I would suggest 'Age of Autism' and Suzanne Humphries 'Dissolving Illusions'. I'd seen VAXXED and knew very well the story of Dr. Andy Wakefield's crucifixion by the medical community and media. So much vitriol over a little study suggesting a possible link between a vaccine and immune system disregulation. Where are we as a society, as a scientific community, if we attack a person who publishes a study recommending more research on the issue (as nearly EVERY scientific paper does). Frankly, I thought the movie VAXXED barely scraped the iceberg on the possible link between vaccines and autism. You'd be better served by first watching the hundreds of testimonials being captured and posted on YouTube as part of the VAXXED bus tour. This is perhaps THE MOST IMPORTANT story in medicine right now. The public needs to know whether vaccines are safe for each and every individual. A vaccine schedule that has accelerated from 12 to 72 vaccines in the last 30 years without any collective research as to the possible effects of not just Mercury and aluminum, not just the additives like polysorbate 80 and mono sodium glutamate, but the viral strains themselves. Presuming viruses as static entities, unable to mutate into more dangerous and virulent strains denies all we know and have learned about infectious disease in the last 300 years. Finally, Dr. Paul Offit, an apostle of the darkest nature, who has done more damage to scientific discovery and public health than any medical professional in history, who states that you can safely have 10,000 vaccines on the same day (revised from his original 'scientific' estimate of 100,000), I say 'TRY IT YOURSELF'!