ISBN-10:
1118524888
ISBN-13:
9781118524886
Pub. Date:
09/28/2015
Publisher:
Wiley
The Genetics of Neurodevelopmental Disorders / Edition 1

The Genetics of Neurodevelopmental Disorders / Edition 1

by Kevin J. Mitchell

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Product Details

ISBN-13: 9781118524886
Publisher: Wiley
Publication date: 09/28/2015
Pages: 368
Product dimensions: 7.10(w) x 10.00(h) x 0.90(d)

About the Author

Kevin J. Mitchell is an Associate Professor at the Smurfit Institute of Genetics and Institute of Neuroscience at Trinity College Dublin

Table of Contents

List of Contributors vii

Foreword
Kevin J. Mitchell ix

1 The Genetic Architecture of Neurodevelopmental Disorders 1
Kevin J. Mitchell

2 Overlapping Etiology of Neurodevelopmental Disorders 29
Eric Kelleher and Aiden Corvin

3 The Mutational Spectrum of Neurodevelopmental Disorders 49
Nancy D. Merner, Patrick A. Dion, and Guy A. Rouleau

4 The Role of Genetic Interactions in Neurodevelopmental Disorders 69
Jason H. Moore and Kevin J. Mitchell

5 Developmental Instability, Mutation Load, and Neurodevelopmental Disorders 81
Ronald A. Yeo and Steven W. Gangestad

6 Environmental Factors and Gene–Environment Interactions 111
John McGrath

7 The Genetics of Brain Malformations 129
M. Chiara Manzini and Christopher A. Walsh

8 Disorders of Axon Guidance 155
Heike Blockus and Alain Chédotal

9 Synaptic Disorders 195
Catalina Betancur and Kevin J. Mitchell

10 Human Stem Cell Models of Neurodevelopmental Disorders 239
Peter Kirwan and Frederick J. Livesey

11 Animal Models for Neurodevelopmental Disorders 261
Hala Harony-Nicolas and Joseph D. Buxbaum

12 Cascading Genetic and Environmental Effects on Development: Implications for Intervention 275
Esha Massand and Annette Karmiloff-Smith

13 Human Genetics and Clinical Aspects of Neurodevelopmental Disorders 289
Gholson J. Lyon and Jason O'Rawe

14 Progress Toward Therapies and Interventions for Neurodevelopmental Disorders 319
Ayokunmi Ajetunmobi and Daniela Tropea

Subject Index 345

Gene Index 353

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