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Amyloid fibrils are associated with a range of pathological disorders including Alzheimer's Disease, Down's syndrome, diabetes, cardiomyopathies, and transmissible spongiform encephalopathies. This volume is a comprehensive account of recent developments in the understanding of the process of amyloid fibrils. Contains up-to-date data on all of the clinical problems which, despite their pathological significance, are still largely unsolved.
Table of ContentsPARTIAL TABLE OF CONTENTS:
A Molecular Model of the Amyloid Fibril (C. Blake,et al.).
Modulating Conformational Factors in Transthyretin Amyloid (M. Saraiva et al.).
Proteoglycans and Amyloid Fibrillogenesis (R. Kisilevsky & P. Fraser).
Alzheimer's Disease: Genesis of Amyloid (K. Beyreuther, et al.).
Prion Protien Amyloid: Separation of Scrapie Infectivity from PrP Poymers (H. Wille, et al.).
Ageing and Amyloid Fibrillogenesis: Lessons from Apolipoprotein AI, Transthyretin and Islet Amyloid Polypeptide (P. Westermark, et al.).
FAP Mutations Destabilize Transthyretin Facilitating Conformational Changes Required for Amyloid Formation (W. Colon, et al.).