The Pathway for Oxygen: Structure and Function in the Mammalian Respiratory System

The Pathway for Oxygen: Structure and Function in the Mammalian Respiratory System

by Ewald R. Weibel M.D.

Hardcover

$74.50

Overview

It is rare indeed for one book to be both a first-rate classroom text and a major contribution to scholarship. The Pathway for Oxygen is such a book, offering a new approach to respiratory physiology and morphology that quantitatively links the two. Professionalism in science has led to a compartmentalization of biology. Function is the domain of the physiologist, structure that of the morphologist, and they often operate with vastly disparate concepts and procedures. Yet the performance of the respiratory system depends both on structural and on functional properties that cannot be separated.

The first chapter of The Pathway for Oxygen engages the student with the design and function of the vertebrate respiratory organs from a comparative viewpoint. The second chapter adds to that foundation the link between cell energetics and oxygen needs of the whole animal. With Chapter 3 the excitement begins—new ideas, fresh attacks on old problems, and a fuller account of the power of the quantitative approach Dr. Ewald Weibel has pioneered.

The Pathway for Oxygen will be read eagerly by medical students, graduate students, advanced undergraduates in zoology—and by their professors.

Product Details

ISBN-13: 9780674657915
Publisher: Harvard
Publication date: 07/26/1984
Pages: 448
Product dimensions: 6.00(w) x 9.25(h) x (d)

About the Author

Ewald R. Weibel, M.D., is Professor of Anatomy, University of Bern, Switzerland.

Table of Contents

OXYGEN AND THE HISTORY OF LIFE

The Cell's Oxygen Sink and Energetics

Getting Oxygen to the Sink

Evolution of O2 Transport Systems

Evolution of External Gas Exchangers

Looking at the System as a Whole: Philosophy of the Approach

THE BODY'S NEED FOR OXYGEN

Levels of O2 Consumption

Estimating the Limits of O2 Consumption

LINKING STRUCTURE AND FUNCTION: MODEL, MEANS, AND TOOLS

How Does Structure Affect O2 Flow?

Are Animals Built Reasonably?

The Tools

CELL RESPIRATION

Gaining Energy from Combustion

Metabolic Pathways of the Cell

The Cell's Energetic Balance Sheet

MITOCHONDRIA: THE CELL'S FURNACES

Putting Some Order into Cell Metabolism

Oxidation-Phosphorylation Coupling Depends on Structure

Mitochondria and the Cell's Aerobic Potential

Mitochondria in Muscle Cells

THE VEHICLE FOR OXYGEN TRANSPORT: BLOOD AND CIRCULATION

The O2 and CO, Carrier: Blood

Moving Blood Around: Circulation

O2 Transport by the Blood

DELIVERING OXYGEN TO THE CELLS

Distributing Blood to the Tissues: Design of the Vasculature

The Microvascular Unit

O2 Flow from Blood to Cells

DESIGN AND DEVELOPMENT OF THE MAMMALIAN LUNG

Development of the Lung

Lung Histogenesis: Differentiation toward Gas Exchange

The Lung at Birth and Its Postnatal Maturation

LUNG CELL BIOLOGY

Organization of the Lung's Cell Population

A Closer Look at the Cells of the Gas Exchange Region

AIRWAYS AND BLOOD VESSELS

The Airway Tree

Ventilation

The Vascular Trees

Pulmonary Blood Flow

Ventilation-Perfusion Matching

THE LUNG'S MECHANICAL SUPPORT

External Support and Motive Force

The Pleural Cavity

The Lung's Fiber Skeleton

Surface Tension

Micromechanics and the Configuration of the Alveolar Septum

Keeping the Barrier Dry and Thin

THE LUNG AS GAS EXCHANGER

Design of the Gas Exchanger

Physiological Basis for Gas Exchange

Pulmonary Diffusing Capacity: Physiology

Pulmonary Diffusing Capacity: Morphometry

Structure and Function Compared

Matching the Conductance to O2 Needs: The Emergence of a Paradox

Resolving the Paradox: Models and Nature

THE RESPIRATORY SYSTEM IN OVERVIEW

Adjusting Performance to Needs

Adjusting Potential to Needs

The Limits to Potential: The Smallest Mammal

UNITS OF MEASUREMENT

GENERAL REFERENCES

INDEX

What People are Saying About This

This is clearly one of the most outstanding books in physiology/functional anatomy ever to be written.

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