Naltrexone is an opiate antagonist drug developed in the 1970s and approved by the FDA in 1984 for opiate and drug abuse treatment. When used at much lower doses in an off-label protocol referred to as low dose naltrexone (LDN), the drug has been shown to halt disease progression in Crohn’s disease and certain cancers, to reduce symptoms in multiple sclerosis and autism, and to improve numerous autoimmune and neurodegenerative conditions, including Parkinson’s disease and amyotrophic lateral sclerosis (ALS).
Grounded in clinical and scientific research, this book describes the history of naltrexone, its potential therapeutic uses, its effects on the immune system, its pharmacological properties, and how the drug is administered. It also lists fillers and compounding pharmacies, doctors who prescribe LDN, and patient resources, and includes interviews with LDN patients and researchers.
About the Author
Table of ContentsTable of Contents
Foreword by Yash Pal Agrawal, M.D., Ph.D. 1
1. The War on DrugsA History of Naltrexone 11
2. LDN in Autoimmune Diseases 29
3. LDN in Multiple Sclerosis 45
4. LDN in Neurodegenerative Disorders 61
5. LDN in Cancer 78
6. LDN in Autism Spectrum Disorders 95
7. LDN in Wound Healing and Infections 102
8. The Immune System and LDN in HIV/AIDS 108
9. The LDN Experience: A Patient’s Guide to LDN 126
10. The Potential Benefits and Future of LDN 148
Chapter Notes 159
Appendix: Clinical Trials of LDN and Related Compounds 179
Most Helpful Customer Reviews
Elaine Moore and Samantha Wilkinson's (Sammy Jo) book on `Low Dose Naltrexone Therapy' is a much needed book. LDN therapy is an off-label use of an established, FDA approved drug - Naltrexone -- used to help modulate the immune system for autoimmune diseases like MS, Crohn's, and others. However, LDN therapy has also been proven beneficial for cancers by helping to reduce tumor size - in pancreatic cancer for example. The dose of Naltrexone used in LDN therapy is similar to the doses that are used in homeopathic medicines. It's good to have a reference that cites credible professionals describing the safety and efficacy of this therapy.
The information about LDN therapy is presented so that the average person (non medical) can understand the history behind LDN therapy, how LDN therapy works, and offer guidelines to help a patient talk to their doctor about the applicability of LDN therapy for their own health issues. I particularly liked how the writers broke chapters into smaller sections with clear, descriptive headings -- really made for easy reading even though some of the information is very technical.
There are a number of resources included in the book as well as a glossary and index. Specific conditions are also covered - like `autism' for example. Also, information about clinical trials is included. I especially found Sammy Jo's experience with MS and LDN to be very inspiring.
I particularly liked that the writers highlighted that the older theories of autoimmune disease proposed that the immune system was `hyperactive, strong, and easily stimulated'. Whereas new theories accept that the immune system in autoimmune disease is in-fact ` weak and ineffective'. I think this point is important because the confusion between the two theories hinders a lot of possible treatment options / therapies.
However, I think a doctor / medical professional will find the book most beneficial. Doctors don't have a lot of time to research --- this book consolidates a lot of the [current and historical] information about LDN therapy -- available on various websites -- into one place. It also includes information from LDN researchers that were interviewed and offers patient guidelines for a doctor considering prescribing LDN for their patient. I thought it was especially helpful that some LDN experienced doctors agreed to have their names published as a reference. These doctors offer phone consultations which will be helpful for not only for patients who cannot find a doctor willing to prescribe, but perhaps for other doctors as well.
The writers are very clear to point out that LDN therapy is NOT a cure for autoimmune disease nor cancers...but is to be used as a therapy to stop or slow the progression of disease. They also make the important point that larger, clinical trials are needed to allow LDN therapy to become more main stream and so that the larger medical community will become aware of this therapy. I agree with their assessment that a patient should be monitored by their doctor if they decide to try LDN therapy.
I want to thank the writers for creating a reference of information on LDN therapy that I'm sure will be helpful to a lot of people.
Like so many of Elaine Moore's other books, this one takes a complex subject -- in this case how LDN influences biochemical and cellular processes and modifies the regulators of an immune system response -- and puts it into a readable format for almost all levels of readers. It is well-written, engaging, science-based, and resourceful. Moore and her co-author Wilkinson do not portray LDN therapy as a "cure all", having avoided all the pitfalls of foregoing science for false promises, and have instead made the case for LDN use in such chronic diseases as multiple sclerosis, neurodegenerative disorders, Crohn's disease, certain cancers, HIV/AIDS, and autism. The book factually describes the nature of the drug, its protocols, the bioprocesses involved, and what its influence is on various diseases. It also covers the extensive research and discoveries made by such notable scientists as Drs. Zagon and McLaughlin as well as the outcomes of various LDN studies and trials. The "promise" of low dose naltrexone is that it has done so much good for so many, and with further research and study into it, will surely receive further validation. Moore does a remarkable job of covering a lot of ground in one 213-page book. The book also includes a considerable back section of glossary of terms, resources, and list of clinical trials. Hopefully, this book will make its way to the desk of every physician who must treat chronic illnesses as LDN increasingly finds its way into the mainstream.
EVERYONE SHOULD READ THIS BOOK