The Tour Bus of Doom rolls into a small coastal town, spewing zombies to rampage down the main street. To the beat of eerie drum music, they loot, kidnap, and zombie-fy innocent citizens. Spam the cat, self-appointed feline defender of the town, watches in horror from the rooftops. When the zombies abduct Spam's jeweler friend and take over the nursing home, Spam is certain they are also responsible for the disappearance of his next-door neighbor Mr. Barker, partner of retired police dog, Officer Bubba. Then Marigold, Spam's half sister, reports that her human family, who went missing while on a mission of mercy to earthquake ravaged Haiti, has finally returned home, just long enough to take their valuables. And They. Don't. Even. Recognize. Her.
All of that is dire enough, but then the zombies go too far and take over the bodies of the owner and server at Spam's favorite fish'n'chips place. Searching for help from his vampire friend Maddog, Spam meets a new cat in town, the sinuous Havana Brown Erzullie, who arrived with the zombies. Aided (sort of) by her, Renfrew the raccoon, the urban deer cat taxi service, Rocky the vampcat, and his half-siblings Marigold and Mat, the heroic feline must investigate, before the zombie apocalyps-o destroys not only his town, but his home and his beloved Darcy.
Just when he thinks he may have the situation well in paw, the zombie hunters from Seattle arrive, responding to a bounty on the heads of the zombies. What they don't realize is that they have the wrong brand of zombies, the un-plagued un-dead, who could revive as long as they keep their heads.