Theoretical Aspects of Population Genetics. (MPB-4), Volume 4

Theoretical Aspects of Population Genetics. (MPB-4), Volume 4

by Motoo Kimura, Tomoko Ohta


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To show the importance of stochastic processes in the change of gene frequencies, the authors discuss topics ranging from molecular evolution to two-locus problems in terms of diffusion models. Throughout their discussion, they come to grips with one of the most challenging problems in population genetics—the ways in which genetic variability is maintained in Mendelian populations.

R.A. Fisher, J.B.S. Haldane, and Sewall Wright, in pioneering works, confirmed the usefulness of mathematical theory in population genetics. The synthesis their work achieved is recognized today as mathematical genetics, that branch of genetics whose aim is to investigate the laws governing the genetic structure of natural populations and, consequently, to clarify the mechanisms of evolution.

For the benefit of population geneticists without advanced mathematical training, Professors Kimura and Ohta use verbal description rather than mathematical symbolism wherever practicable. A mathematical appendix is included.

Product Details

ISBN-13: 9780691080963
Publisher: Princeton University Press
Publication date: 10/21/1971
Series: Monographs in Population Biology , #4
Pages: 232
Product dimensions: 6.50(w) x 1.50(h) x 9.50(d)

Table of Contents

1.Fate of an Individual Mutant Gene in a Finite Population3
2.Population Genetics and Molecular Evolution16
3.Effective Population Number33
4.Natural Selection and Genetic Loads44
5.Adaptive Evolution and Substitutional Load72
6.Two-locus Problems89
7.Linkage Disequilibrium and Associative Over-dominance in a Finite Population105
8.Breeding Structure of Populations117
9.Maintenance of Genetic Variability in Mendelian Populations141
10.The Role of Sexual Reproduction in Evolution160
Mathematical Appendix167
Author Index215
Subject Index217

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