Thyroid hormone, Volume 106, the latest release in the Vitamins and Hormones series first published in 1943 provides up-to-date information on crystal structures and basic structural studies on neurotrophins and their receptors, neurotrophin functions and the biological actions of neurotrophins related to clinical conditions and disease. This new release focuses on timely topics, including the Nuclear Import and Export of the Thyroid Hormone Receptor, the Thyroid hormone and the white matter of the central nervous system: from development to repair, Thyroid hormone and astrocyte differentiation, and the Molecular Basis of Nongenomic Actions of Thyroid Hormone, amongst other topics.
- Presents the latest information on thyroid hormone
- Provides a long-running series that focuses on updates and advances in vitamins and hormones
- Covers single molecules or diseases that are related to vitamins or hormones, with the topic broadly interpreted to include related substances
About the Author
Dr. Gerald Litwack obtained M.S. and PhD degrees from the University of Wisconsin Department of Biochemistry and remained there for a brief time as a Lecturer on Enzymes. Then he entered the Biochemical Institute of the Sorbonne as a Fellow of the National Foundation for Infantile Paralysis. He next moved to Rutgers University as an Assistant Professor of Biochemistry and later as Associate Professor of biochemistry at the University of Pennsylvania Graduate School of Medicine. After four years he moved to the Temple University School of Medicine as Professor of Biochemistry and Deputy Director of the Fels Institute for Cancer Research and Molecular Biology, soon after, becoming the Laura H. Carnell Professor. Subsequently he was appointed chair of Biochemistry and Molecular Pharmacology at the Jefferson Medical College as well as Vice Dean for Research and Deputy Director of the Jefferson Cancer Institute and Director of the Institute for Apoptosis. Following the move of his family, he became a Visiting Scholar at the Department of Biological Chemistry of the Geffen School of Medicine at UCLA and then became the Founding Chair of the Department of Basic Sciences at the Geisinger Commonwealth School of Medicine, becoming Professor of Molecular and Cellular Medicine and Associate Director of the Institute for Regenerative Medicine at the Texas A&M Health Science Center as his final position. During his career he was a visiting scientist at the University of California, San Francisco and Berkeley, Courtauld Institute of Biochemistry, London and the Wistar Institute. He was appointed Emeritus Professor and/or Chair at Rutgers University, Thomas Jefferson University and the Geisinger Commonwealth School of Medicine. He has published more than 300 scientific papers, authored three textbooks and edited more than sixty-five books. Currently he lives with his family and continues his authorship and editorial work in Los Angeles.
Table of Contents
1. Local Regulation of Thyroid Hormone Signaling Alexander G. Little 2. Thyroid Hormone Transport and Transporters Doreen Braun and Ulrich Schweizer 3. Nuclear Import and Export of the Thyroid Hormone Receptor Jibo Zhang, Vincent R. Roggero and Lizabeth A. Allison 4. Molecular Basis of Nongenomic Actions of Thyroid Hormone Paul J. Davis, Jack L. Leonard, Hung-Yun Lin, Matthew Leinung and Shaker A. Mousa 5. The Mechanism of Negative Transcriptional Regulation by Thyroid Hormone: Lessons From the Thyrotropin β Subunit Gene Shigekazu Sasaki, Akio Matsushita, Go Kuroda, Hiroko M. Nakamura, Yutaka Oki and Takafumi Suda 6. Thyroid Autoimmunity: An Interplay of Factors Stephen J. Merrill and Sarah B. Minucci 7. Thyroid Hormone Receptor Antagonists: From Environmental Pollution to Novel Small Molecules Louise S. Mackenzie 8. Thyroid Hormone Stimulation of Adult Brain Fatty Acid Oxidation Mikaela M. Sifuentes and James D. Lechleiter 9. The NF-κB Family of Transcription Factors and Its Role in Thyroid Physiology Carla Reale, Tiziana Zotti, Ivan Scudiero, Pasquale Vito and Romania Stilo 10. Thyroid Hormone Regulation of Adult Neurogenesis Sashaina E. Fanibunda, Lynette A. Desouza, Richa Kapoor, Rama A. Vaidya and Vidita A. Vaidya 11. Thyroid Hormone and the White Matter of the Central Nervous System: From Development to Repair Laura Calzà, Vito A. Baldassarro, Mercedes Fernandez, Alessandro Giuliani, Luca Lorenzini and Luciana Giardino 12. Thyroid Hormone and Astrocyte Differentiation Moitreyi Das, Mousam Ghosh, Kusumika Gharami and Sumantra Das 13. Thyroid Hormone in the CNS: Contribution of Neuron–Glia Interaction Mami Noda 14. Thyroid Hormone Signaling in Retinal Development, Survival, and Disease Fan Yang, Hongwei Ma and Xi-Qin Ding 15. Thyroid Hormone Signaling in the Development of the Endochondral Skeleton Richard C. Lindsey, Patrick Aghajanian and Subburaman Mohan 16. Thyroid Hormone and Skeletal Development Cecilia H.A. Gouveia, M. Miranda-Rodrigues, G.M. Martins and B.N. Papi 17. Thyroid Hormone Role and Economy in the Developing Testis Arturo Hernandez 18. Signaling Pathways in Thyroid Cancer Shan Jin, Yun-Tian Yang and Wuyuntu Bao 19. Roles of Thyroid Transcription Factor 1 in Lung Cancer Biology Cody A. Phelps, Shao-Chiang Lai and David Mu