Increasingly viewed as the future of medicine, the field of tissue engineering is still in its infancy. As evidenced in both the scientific and popular press, there exists considerable excitement surrounding the strategy of regenerative medicine. To achieve its highest potential, a series of technological advances must be made. Putting the numerous breakthroughs made in this field into a broad context, Tissue
Engineering disseminates current thinking on the development of engineered tissues.
Divided into three sections, the book covers the fundamentals of tissue engineering, enabling technologies, and tissue engineering applications. It examines the properties of stem cells, primary cells, growth factors, and extracellular matrix as well as their impact on the development of tissue engineered devices. Contributions focus on those strategies typically incorporated into tissue engineered devices or utilized in their development, including scaffolds, nanocomposites, bioreactors, drug delivery systems, and gene therapy techniques. Finally, the book presents synthetic tissues and organs that are currently under development for regenerative medicine applications.
The ability to engineer biocompatible tissue is the hallmark of modern biomedical engineering,
integrating all aspects of every sub-discipline in the field. Featuring chapters drawn from the third edition of the best-selling Handbook of Biomedical Engineering as well as new contributions not found in the handbook, Tissue Engineering surveys the latest advances in this relatively young area. The contributing authors are a diverse group with backgrounds in academia, clinical medicine, and industry.
Furthermore, the text includes contributions from Europe, Asia, and North America, helping to broaden the views on the development and application of tissue engineered devices.
|Series:||Advances in Experimental Medicine and Biology Series , #585|
|Product dimensions:||6.10(w) x 9.25(h) x 0.04(d)|
Table of Contents
Stem Cells.- “Stem Cells into Liver” - Basic Research and Potential Clinical Applications.- Mesenchymal Stem Cells Increase Self-Renewal of Small Intestinal Epithelium and Accelerate Structural Recovery after Radiation Injury.- Optimizing Viral and Non-Viral Gene Transfer Methods for Genetic Modification of Porcine Mesenchymal Stem Cells.- Transplantation of Bone Marrow Stromal Cells for Treatment of Central Nervous System Diseases.- Soluble and Insoluble Signals.- Chondrocyte Signaling and Artificial Matrices for Articular Cartilage Engineering.- Osteoinduction with Colloss®, Colloss® E, and GFm.- Biglycan Is a Positive Modulator of BMP-2 Induced Osteoblast Differentiation.- Use of Neopterin as a Bone Marrow Hematopoietic and Stromal Cell Growth Factor in Tissue-Engineered Devices.- Scaffolds and Matrix Design.- Injectable Synthetic Extracellular Matrices for Tissue Engineering and Repair.- Temporal Changes in PEG Hydrogel Structure Influence Human Mesenchymal Stem Cell Proliferation and Matrix Mineralization.- Novel Biophysical Techniques for Investigating Long-Term Cell Adhesion Dynamics on Biomaterial Surfaces.- Evaluation of Various Types of Scaffold for Tissue Engineered Intervertebral Disc.- Physicochemical Characterization of Photopolymerizable Plga Blends.- Porous Tantalum Trabecular Metal Scaffolds in Combination with a Novel Marrow Processing Technique to Replace Autograft.- Preparation of Sponge Using Porcine Small Intesinal Submucosa and Their Applications as a Scaffold and a Wound Dressing.- Bioreactor and Assessment Technologies.- Modulation of Cell Differentiation in Bone Tissue Engineering Constructs Cultured in a Bioreactor.- Bioreactors for Tissues of the Musculoskeletal System.- Non-Invasive Monitoring of Tissue-Engineered Pancreatic Constructs by NMR Techniques.- Animal Models and Clinical Strategies.- From Molecules to Matrix: Construction and Evaluation of Molecularly Defined Bioscaffolds.- Age-Related Differences in Articular Cartilage Wound Healing: A Potential Role for Transforming Growth Factor1 in Adult Cartilage Repair.- Intrinsic Versus Extrinsic Vascularization in Tissue Engineering.- Predictive Value of In Vitro and In Vivo Assays in Bone and Cartilage Repair — What do They Really Tell Us about the Clinical Performance?.- Science, Regulation, and The Public.- Engineered Tissues: The Regulatory Path from Concept to Market.- Tissue Engineering Strategies.- Fibrin in Tissue Engineering.- Ectopic Bone Induction by Equine Bone Protein Extract.- Adipose Tissue Induction In Vivo.- Ocular Tissue Engineering.- Molecular Mechanism of Osteochondroprogenitor Fate Determination During Bone Formation.