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Toxicology Handbook / Edition 3

Toxicology Handbook is a practical evidence-based guide on the care of the poisoned patient.

This concise text is informed by the latest clinical research and takes a rigorous and structured risk assessment-based approach to decision making in the context of clinical toxicology.

It assists the clinician to quickly find information on poisons, toxins, antidotes, envenomings and antivenoms and determine the appropriate treatment for the acutely poisoned patient.

• Guides clinicians through drug administration and treatment
• Includes 'handy tips' and 'pitfalls'
• Incorporates drug dosages and administration are based on current pharmacological regulations

• Content on drug dosage and administration based on the most up-to-date pharmacological regulations on toxicology
• Geographical locations of envenomings from snakes, spiders and jellyfish are portrayed on illustrated maps
• New subchapters include Newer oral anticoagulants (NOACs) and Paracetamol: Modified release formulations

Product Details

ISBN-13: 9780729542241
Publisher: Elsevier Health Sciences
Publication date: 04/02/2015
Edition description: New Edition
Pages: 560
Sales rank: 573,176
Product dimensions: 6.00(w) x 1.25(h) x 9.00(d)

Table of Contents

CHAPTER 1 APPROACH TO THE POISONED PATIENT 1.1Overview 1.2Resuscitation 1.3Risk assessment 1.4Supportive care and monitoring 1.5Investigations 1.6Gastrointestinal decontamination 1.7Enhanced elimination 1.8Antidotes 1.9Disposition

CHAPTER 2 SPECIFIC CONSIDERATIONS 2.1Approach to snakebite 2.2Approach to mushroom poisoning 2.3Approach to plant poisoning 2.4Coma 2.5Hypotension 2.6Seizures 2.7Delirium and agitation 2.8Serotonin syndrome 2.9Anticholinergic syndrome 2.10Cholinergic syndrome 2.11Neuroleptic malignant syndrome 2.12Alcohol use disorder 2.13Amphetamine use disorder 2.14Opioid use disorder 2.15Sedative-hypnotic use disorder 2.16Solvent abuse 2.17Body packers and stuffers 2.18Osmolality and the osmolar gap 2.19Acid – base disorders 2.20The 12-lead ECG in toxicology 2.21Poisoning during pregnancy and lactation 2.22Poisoning in children 2.23Poisoning in the elderly

CHAPTER 3 SPECIFIC TOXINS 3.1Alcohol: Ethanol 3.2Alcohol: Ethylene glycol 3.3Alcohol: Isopropanol (isopropyl alcohol) 3.4Alcohol: Methanol (methyl alcohol) 3.5Alcohol: Other toxic alcohols 3.6Amiodarone 3.7Amisulpride 3.8Amphetamines 3.9Angiotensin converting enzyme inhibitors 3.10Anticoagulant rodenticides 3.11Anticonvulsants: Newer agents 3.12Antihistamines (non-sedating) 3.13Antihistamines (sedating) 3.14Arsenic 3.15Baclofen 3.16Barbiturates 3.17Benzodiazepines 3.18Benztropine 3.19Beta-blockers 3.20Bupropion 3.21Button batteries 3.22Calcium channel blockers 3.23Cannabinoids (marijuana) 3.24Carbamazepine 3.25Carbon monoxide 3.26Chloroquine and hydroxychloroquine 3.27Chloral hydrate 3.28Clonidine 3.29Clozapine 3.30Cocaine 3.31Colchicine 3.32Corrosives 3.33Cyanide 3.34Digoxin: Acute overdose 3.35Digoxin: Chronic poisoning 3.36Diphenoxylate-atropine 3.37Gamma-hydroxybutyrate (GHB) 3.38Glyphosate 3.39Hydrocarbons 3.40Hydrofluoric acid 3.41Hydrogen peroxide 3.42Insulin 3.43Iron 3.44Isoniazid 3.45Lead 3.46Lithium: Acute overdose 3.47Lithium: Chronic poisoning 3.48Local anaesthetic agents 3.49Mercury 3.50Metformin 3.51Methotrexate 3.52Mirtazapine 3.53Monoamine oxidase inhibitors (MAOIs) 3.54Newer oral anticoagulants (NOACs) 3.55Non-steroidal anti-inflammatory drugs (NSAIDs) 3.56Olanzapine 3.57Opioids 3.58Organochlorines 3.59Organophosphorus agents (organophosphates and carbamates) 3.60Paracetamol: Acute overdose 3.61Paracetamol: Modified-release formulations 3.62Paracetamol: Repeated supratherapeutic ingestion 3.63Paraquat 3.64Phenothiazines and butyrophenones (antipsychotic agents) 3.65Phenytoin 3.66Potassium chloride 3.67Quetiapine 3.68Quinine 3.69Risperidone 3.70Salicylates 3.71Selective serotonin reuptake inhibitors (SSRIs) 3.72Strychnine 3.73Sylfonyureas 3.74Theophylline 3.75Thyroxine 3.76Tramadol 3.77Tricyclic antidepressants (TCAs) 3.78Valproic acid (sodium valproate) 3.79Venlafaxine and desvenlafaxine 3.80Warfarin

CHAPTER 4 ANTIDOTES 4.1Atropine 4.2Calcium 4.3Cyproheptadine 4.4Desferrioxamine 4.5Dicobalt edetate 4.6Digoxin immune Fab 4.7Dimercaprol 4.8Ethanol 4.9Flumazenil 4.10Folinic acid 4.11Fomepizole 4.12Glucose 4.13Hydroxocobalamin 4.14Insulin (high dose) 4.15Intravenous lipid emulsion 4.16Methylene blue 4.17N-acetylcysteine 4.18Naloxone 4.19Octreotide 4.20Penicillamine 4.21Physostigmine 4.22Pralidoxime 4.23Pyridoxine 4.24Sodium bicarbonate 4.25Sodium calcium edetate 4.26Sodium thiosulfate 4.27Succimer 4.28Vitamin K

CHAPTER 5 ENVENOMINGS 5.1Black snake 5.2Brown snake 5.3Death adder 5.4Tiger snake group 5.5Taipan 5.6Sea snake 5.7Australian scorpions 5.8Bluebottle jellyfish (Physalia species) 5.9Stonefish 5.10Box jellyfish (Chironex fleckeri) 5.11Irukandji syndrome 5.12Blue-ringed octopus 5.13Redback spider 5.14Funnel-web (big black) spider 5.15White-tailed spider 5.16Ticks

CHAPTER 6 ANTIVENOMS 6.1CSL Black Snake Antivenom 6.2CSL Brown Snake Antivenom 6.3CSL Death Adder Antivenom 6.4CSL Tiger Snake Antivenom 6.5CSL Taipan Antivenom 6.6CSL Sea Snake Antivenom 6.7CSL Polyvalent Snake Antivenom 6.8CSL Stonefish Antivenom 6.9CSL Box Jellyfish Antivenom 6.10CSL Redback Spider Antivenom 6.11CSL Funnel-web Spider Antivenom

APPENDICES Appendix 1 Poison Information Telephone Numbers Appendix 2 Example ECGs Appendix 3 Conversion factors and therapeutic ranges for important toxins Appendix 4 Alcohol pathways Appendix 5 Therapeutic over-warfarinisation Appendix 6 Management of allergic reactions to antivenoms

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