Translational Control of Gene Expression

Translational Control of Gene Expression

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Overview

Translational Control of Gene Expression by Nahum Sonenberg

Since the 1996 publication of Translational Control, there has been fresh interest in protein synthesis and recognition of the key role of translational control mechanisms in regulating gene expression. This new monograph updates and expands the scope of the earlier book but it also takes a fresh look at the field. In a new format, the first eight chapters provide broad overviews, while each of the additional twenty-eight has a focus on a research topic of more specific interest. The result is a thoroughly up-to-date account of initiation, elongation, and termination of translation, control mechanisms in development in response to extracellular stimuli, and the effects on the translational machinery of virus infection and disease. This book is essential reading for students entering the field and an invaluable resource for investigators of gene expression and its control.

Product Details

ISBN-13: 9780879696184
Publisher: Cold Spring Harbor Laboratory Press
Publication date: 10/28/2001
Series: Monographs Series
Edition description: 2ND
Pages: 1020
Product dimensions: 6.04(w) x 9.08(h) x 1.70(d)

Table of Contents

Preface

Chapter 1: Origins and Principles of Translational Control

Chapter 2: Pathway and Mechanism of Initiation of Protein Synthesis

Chapter 3: Protein Bioynthesis Elongation Cycle

Chapter 4: Comparative View of Initiation Site Selection Mechanisms

Chapter 5: Mechanism and Regulation of Initiator Methionyl-tRNA Binding to Ribosomes

Chapter 6: Regulation of Ribosomal Recruitment in Eukaryotes

Chapter 7: Translational Control of Developmental Decisions

Chapter 8: Viral Translational Strategies and Host Defense Mechanisms

Chapter 9: Ribosomal Subunit Joining

Chapter 10: Physical and Functional Interactions between the mRNA Cap Structure and the Poly(A) Tail

Chapter 11: Translation Termination: It's Not the End of the Story

Chapter 12: Genetic Approaches to Translation Initiation in Saccharomyces cerevisiae

Chapter 13: Double-stranded RNA-activated Protein Kinase PKR

Chapter 14: Heme-regulated eIF2 alpha Kinase

Chapter 15: PERK and Translational Control by Stress in the Endoplasmic Reticulum

Chapter 16: Regulation of Translation Initiation in Mammalian Cells by Amino Acids

Chapter 17: Translational Control during Heat Shock

Chapter 18: Translational Control by Upstream Open Reading Frames

Chapter 19: Cellular Internal Ribosome Entry Site Elements and the Use of cDNA Microarrays in Their Investigation

Chapter 20: Translational Control and Cancer

Chapter 21: Translational Control of Ferritin Synthesis

Chapter 22: Translational Control of TOP mRNAs

Chapter 23: S6 Phosphorylation and Signal Transduction

Chapter 24: Control of the Elongation Phase of Protein Synthesis

Chapter 25: Programmed Translational Frameshifting, Hopping, and Readthrough of Termination Codons

Chapter 26: Recoding UGA as Selenocysteine

Chapter 27: Influence of Polyadenylation-induced Translation on Metazoan Development and Neuronal Synaptic Function

Chapter 28: Interaction of mRNA Translation and mRNA Degradation in Saccharomyces cerevisiae

Chapter 29: Destabilization of Nonsense-containing Transcripts in Saccharomyces cerevisiae

Chapter 30: Nonsense-mediated RNA Decay in Mammalian Cells: A Splicing-dependent Means to Down-regulate the Levels of mRNAs That Prematurely Terminate Translation

Chapter 31: Translation Initiation on Picornavirus RNA

Chapter 32: Adenovirus Inhibition of Cellular Protein Synthesis and Preferential Translation of Viral mRNAs

Chapter 33: Reovirus Translational Control

Chapter 34: Translational Reprogramming during Influenza Virus Infection

Chapter 35: Translational Control in Poxvirus-infected Cells

Chapter 36: Nontranslational Functions of Components of the Translational Apparatus

Index

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