Translational Gtpases available in Paperback
- Pub. Date:
- VDM Verlag
GTP- and GDP-bound states via regulated cycles of GTP
hydrolysis and exchange of GDP for GTP. The exchange of GDP for GTP is accelerated by the GDP/GTP Exchange
Factor (GEF), while hydrolase activity of the GTPase is stimulated by the GTPase-Activating Protein (GAP).
The conformation of the GTPase in complex with GTP
usually differs from that in complex with GDP, and these structural changes serve as a signal for a partner molecule, inducing changes in its conformation.
This book provides a comprehensive overview of the state of the art in trGTPase research, touching upon structural, biochemical and thermodynamical aspects and would be a useful reference for anybody interested in the mechanisms and regulation of protein biosynthesis.