Treatment of Primary Glomerulonephritis / Edition 3

by Claudio Ponticelli, Richard J. Glassock

Overview

Primary glomerulonephritis is one of the most frequent renal diseases, and a main cause of end-stage kidney disease. Glomerulonephritis has multiple subtypes, each with different physiopathologies, clinical presentations, and management requirements, which makes treatment difficult. As a complex set of diseases, the choice of symptomatic and specific treatment is critical to ameliorating the relentless course of glomerulonephritis.

Focusing on all aspects of primary glomerulonephritis, from their epidemiologies and classification, to their pathogenesis and treatment, this third edition of Treatment of Primary Glomerulonephritis has been fully updated to include the latest research and evidence-based practice. With a strong emphasis on drugs used for both symptomatic and specific treatments, mechanisms of action, effectiveness, and potential toxicity are considered for therapeutic strategies in the different subtypes of primary glomerulonephritis.

Each chapter follows a clear and logical format, allowing easy access to key information. Featuring over 20 full-colour histological images of different diseases to aid diagnosis, and with commentary from internationally recognised experts in the field, this new edition is an essential resource for all practising or academic clinical nephrologists.

Product Details

ISBN-13:	9780198784081
Publisher:	Oxford University Press
Publication date:	08/06/2019
Series:	Oxford Clinical Nephrology Series
Edition description:	3rd ed.
Pages:	640
Product dimensions:	6.10(w) x 9.10(h) x 1.30(d)

About the Author

Claudio Ponticelli, Past Director of the Division of Nephrology, Istituto Scientifico Ospedale Maggiore Policlinico, Milan, Italy,Richard J. Glassock, Emeritus Professor, The David Geffen School of Medicine at the University of California Los Angeles, California, USA

Claudio Ponticelli is an acknowledged expert in the field of nephrology, particularly in glomerular diseases and kidney transplantation. In glomerular diseases, he devised an original therapeutic schedule in primary membranous nephropathy, and has also co-ordinated randomised clinical trials in minimal change disease, focal glomerular sclerosis, and IgA nephropathy. During his career, Professor Ponticelli has been a member of the Council of the Italian Society of Nephrology, the Italian-American Society of Nephrology, and served as the President of the Italian Society of Nephrology. He has received numerous awards, including the ERA/EDTA Award for outstanding scientific achievements.

Richard J. Glassock is an internationally recognised expert in the field of glomerular diseases and clinical nephrology. Currently Professor Emeritus at the David Geffen School of Medicine at UCLA, he is the past-president of the American Society of Nephrology, the National Kidney Foundation (USA), and past-Chairman of the American Board of Internal Medicine. Over his career he has been a visiting professor at over 100 academic institutions, and founded the NephSAP Journal of the American Society of Nephrology as Editor-in-Chief. He has received numerous awards and distinguished lectureships, including the David Hume Memorial Award of the National Kidney Foundation.

Table of Contents

1. A definition, modern classification, and global epidemiology of primary glomerulonephritis, Claudio Ponticelli and Richard Glassock
2. Symptomatic therapy, Richard Glassock
3. The pharmacology of old and new agents for specific therapy of primary glomerular diseases, Claudio Ponticelli and Richard Glassock
4. Minimal change disease, Claudio Ponticelli, Richard Glassock, and Rosanna Coppo
5. Focal and segmental glomerular sclerosis, Claudio Ponticelli, Richard Glassock, and Francesco Scolari
6. Membranous nephropathy, Claudio Ponticelli, Richard Glassock, and Patrizia Passerini
7. Immunoglobulin A nephropathy, Richard Glassock, Claudio Ponticelli, and Kar Neng Lai
8. Infection-related and renal-limited glomerulonephritis, Richard Glassock, Lee Hebert, Gabriella Moroni, and Claudio Ponticelli
9. C3 Glomerulopathies and 'idiopathic' immune complex membranoproliferative glomerulonephritis, Richard Glassock and Fernando C. Fervenza
10. Renal-limited vasculitis, Richard Glassock and Patrick Nachman
11. Other primary glomerular diseases, Claudio Ponticelli and Gabriella Moroni

Editorial Reviews

Reviewer: Muhammad Rafi Ud Din, MD (University of Kentucky College of Medicine)
Description: Appearing 12 years after the first edition, this revised, second edition of a book on glomerulonephritis keeps the same format of multiple short chapters.
Purpose: The goals are to offer comprehensive information and detailed discussion on the rationale, specifics, efficacy, toxicity, and limitations of current therapy as there has been tremendous development in the area of immune-modulating treatment options for various forms of primary glomerulonephritis since the last edition. This book responds well to the continued need for updated, well-organized information in this area where most guidelines and recommendations are still based on opinion.
Audience: It is written primarily for nephrology and glomerular disease specialists, as well as general internists and trainees caring for patients with primary glomerular diseases. A fresh view is being offered by a large number of international authors (authorities in their fields) and the newly assigned section editors.
Features: The book uses a standard design of black-and-white print with a colorful atlas in the middle to describe salient features of different primary glomerulonephritis with some immunofluorescence and electron micrographs. It provides a brief introduction to pathogenesis, etiology, epidemiology, and clinical presentation of glomerular diseases. It then details medical management, based on a critical review of the best available randomized clinical trials. In controversial areas, or the ones lacking definitive clinical studies, the authors provide their personal views and approach to treatment. Also, the first three chapters of the book describe the symptomatic therapy, pharmacology of glucocorticoids, and newer immune-modulating agents. The last chapter covers the less common form of glomerular diseases and recurrent glomerular diseases in the transplanted kidney. It provides diagnostic and treatment algorithms and tables of commonly used drugs. There are plenty of updated references, but placing them in the middle of sentences is rather distracting. The index is good but not complete. There are a few new topics, including transplant immunology and immunosuppression.
Assessment: This is an excellent addition to the currently available publications on medical management of glomerular diseases. It has its own niche because it offers in-depth discussions, critiques, and referenced coverage of key trials that influence decision making. It is rather comprehensive in its coverage and easy to read. However, given the lengthy discussion and lack of specific recommendations, it would be difficult for busy clinicians to use it as a quick reference. What I personally appreciate is the fact that it specifically tackles issues that are either controversial or not well understood.

Doody's Review Service

"This is an excellent addition to the currently available publications on medical management of glomerular diseases. It has its own niche because it offers in-depth discussions, critiques, and referenced coverage of key trials that influence decision making. It is rather comprehensive in its coverage and easy to read."—Doody's

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