Tryptophan, Serotonin, and Melatonin: Basic Aspects and Applications / Edition 1

by Gerald Huether, Walter Kochen, Thomas J. Simat, Hans Steinhart

Overview

This volume contains the proceedings of the Ninth Meeting of the "International Study Group for Tryptophan Research" (lSTRY), held at the University of Hamburg, Germany, from October 10 to 14, 1998. At this meeting the recent developments in the field of tryptophan research were presented by leading researchers from all over the world in 81 oral and 48 poster contributions. Research on tryptophan and its derivatives provides an inexhaustible subject. At the conference we tried to compose a multifacetted picture of the recent investigations through contributions from the major disciplines involved. Thus, we tried to strike a balance between basic research topics and clinical, nutritional or industrial applications. We offered workshops on tryptophan (in sleep and mood), melatonjn, IDO-acti­ vation and the eosinophilia-myalgia syndrome (EMS) as a platform for intensive discussion for the participants. In these proceedings many contributions are multidisciplinary and have practical or theoretical implications for different research fields. Hence, we have organized this volume in nine main chapters according to basic disciplines and subjects. We are aware that this classification is artificial, but we hope that it is the best compromise for contributors and readers.

Product Details

ISBN-13:	9780306462047
Publisher:	Springer US
Publication date:	10/31/1999
Series:	Advances in Experimental Medicine and Biology , #467
Edition description:	1999
Pages:	852
Product dimensions:	7.01(w) x 10.00(h) x 0.07(d)

Table of Contents

Preface. Acknowledgements. 1: Psychiatry. 1.1. Basic Aspects. 1.2. Tryptophan Depletion. 1.3. Tryptophan and Melatonin Supplementation. 1.4. Appetite and Eating Disorders. 2: Neurology. 2.1. Basic Aspects. 2.2. Encephalopathy. 2.3. Migraine and Headache. 3: Pharmacology. 3.1. Neuropharmacology. 3.2. Clinical and Preclinical Pharmacology. 4: Medicinal and Pharmaceutical Chemistry. 4.1. Pathological Aspects. 4.2. Physiological Aspects. 4.3. Radical Scavenger and Antioxidants. 5: Toxicology. 5.1. Effects of Tryptophan Derived Compounds. 5.2. Effects of Toxins on Tryptophan Metabolism. 5.3. Eosinophilia-Myalgia Syndrome (EMS). 6: Immunology. 6.1. Basic Aspects. 6.2. Tryptophan Catabolism in Inflammatory Diseases. 7: Biochemistry. 7.1. Enzymology. 7.2. Pigmentation. 8: Agricultural and Food Sciences. 8.1. Food Science. 8.2. Nutrition. 8.3. Animal Nutrition. 9: Analytical Chemistry. 9.1. Applied Spectroscopy. 9.2. Chromatography and Biosensors.

Editorial Reviews

From an October 1998 international gathering in Hamburg, 106 papers focus on the role of tryptophan, of tryptophan metabolites<-- >especially serotonin and melatonin<-->with regard to brain function in health and disease. They pivot on the general themes of psychiatry, neurology, pharmacology, medicinal and pharmaceutical chemistry, toxicology, immunology, biochemistry, agricultural and food studies, and analytical chemistry. Among the topics most discussed are the regulation of the formation and the release of melatonin, its normal physiological functions, alterations of its production in certain diseases, its possible actions as a radical scavenger, and therefore its possible therapeutic potential; the Eosinophilia-Myalgia Syndrome caused by the intake of contaminated tryptophan preparations and the consequence of the disaster for quality management in manufacturing tryptophan; and the interactions of tryptophan and its various metabolites with immune responses. Annotation c. Book News, Inc., Portland, OR (booknews.com)

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