David Fisher, MD, PhD, and an authoritative panel of academic, cutting-edge researchers review and summarize the current state of the field. Describing the broad roles of tumor suppressors from a perspective based in molecular biology and genetics, the authors detail the major suppressors and the pathways they regulate, including cell cycle progression, stress responses, apoptosis, and responses to DNA damage. Leading-edge and forward-looking, Tumor Suppressor Genes in Human Cancer illuminates what is currently known of tumor suppressor genes and their regulation, work that is already beginning to revolutionize cancer target elucidation, drug discovery, and treatment design.
Table of ContentsPart I. Analysis and Clinical Implications of Tumor Suppressor Genes. Animal Models for Tumor Suppressor Genes, Jordan A. Kreidberg and Thomas A. Natoli. Viral Oncoproteins as Probes for Tumor Suppressor Function, Srikmar P. Chellappan. Tumor Suppressors in Metastasis, Taoufik Ouatas, Melanie T. Hartsough, and Patricia S. Steeg. Apoptosis: Machinery of Cell Death in Development and Cancer, Jinyan Du and David E. Fisher. Drug Discovery in Oncology, Alex Matter. Part II. Tumor Suppressor Pathways. Retinoblastoma Protein in Growth Control and Differentiation, Lilia Stepanova and J. Wade Harper. p53 Tumor Suppressor Protein, Margaret Ashcroft and Karen H. Vousden. p16 Tumor Suppressor, Alexander Kamb and Ken McCormack. DNA Mismatch Repair in Tumor Suppression, Guo-Min Li, Scott McCulloch, and Liya Gu. PTEN: Regulator of Phosphoinositide 3-Kinase Signal Transduction, Jen Jen Yeh and William R. Sellers. Neurofibromatoses, André Bernards and Andrea I. McClatchey. Von Hippel-Lindau Disease: Clinical and Molecular Aspects, Othon Iliopoulos and William G. Kaelin Jr. Wilms' Tumor: A Developmental Anomaly, Aswin L. Menke and Nick D. Hastie. The Fanconi Anemia Pathway and Cancer Susceptibility, Yanan Kuang, Irene Garcia-Higuera, Eric Nisbet-Brown, Anna Savoia, and Alan D. D'Andrea. Index.